# US 10,946,118 B2 · Wound healing device > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,946,118 B2 - Document ID: US10946118B2 - Status: Granted - Kind: B2 - Application number: 15/882,335 - Filed: 2018-01-29 - Published: 2018-06-07 - Granted: 2021-03-16 - Earliest claimed: 2009-06-16 - Assignees: TheraDep Technologies, Inc. - Applicants: TheraDep Technologies, Inc. - Inventors: Joe O'Keeffe; Peter Dobbyn; John Gerard O'Donoghue; Liam O'Neill - Web page: https://patentgrep.com/patent/US10946118B2 ## CPC - A61L 26/0057: {Ingredients of undetermined constitution or reaction products thereof} - A61L 2/14: Plasma, i.e. ionised gases - A61L 26/0019: {obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds} - A61L 26/0023: {Polysaccharides} - A61L 26/0033: {Collagen} - A61L 26/0042: {Fibrin; Fibrinogen} - A61L 26/0066: {Medicaments; Biocides} - A61L 26/009: {Materials resorbable by the body} - H05H 1/42: with provisions for introducing materials into the plasma, e.g. powder or liquid {(arc stabilising or constricting arrangements H05H1/3405; coaxial protecting fluids H05H1/341)} - A61B 18/042: {using additional gas becoming plasma} - A61L 2/02: using physical processes - A61L 2103/05: Living organisms or biological materials - A61L 2300/254: Enzymes, proenzymes - A61L 2300/258: Genetic materials, DNA, RNA, genes, vectors, e.g. plasmids - A61L 2300/404: Biocides, antimicrobial agents, antiseptic agents - A61L 2300/412: Tissue-regenerating or healing or proliferative agents - A61L 2300/606: Coatings - A61L 2300/64: Animal cells - B05D 1/62: {Plasma-deposition of organic layers (plasma deposition in general C23C14/00, C23C16/00)} - H05H 1/471: {Pointed electrodes} - H05H 2240/20: Non-thermal plasma - H05H 2245/34: Skin treatments, e.g. disinfection or wound treatment - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - H05H: PLASMA TECHNIQUE (apparatus or processes specially adapted for producing X-rays H05G2/00); PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - B05D: PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL (conveying articles or workpieces through baths of liquid B65G, e.g. B65G49/02) ## Abstract A plasma coating device for treating a wound comprises a plasma chamber having: one or more electrodes, a gas supply inlet, a plasma outlet exposed to ambient pressure, and an ignition system operatively connected to the electrodes for providing a non-thermal equilibrium plasma within the plasma chamber. An aerosol delivery system is operable to introduce a bioresorbable material as an aerosol into the plasma, to produce a coating on the wound surface. ## Claims ### Claim 1 A method for treating a patient, the method comprising: generating a non-thermal equilibrium plasma at a frequency between 100 kHz and 500 kHz via an electrode housed in a plasma chamber with a wall opposite an outlet exposed to ambient pressure, wherein the electrode extends through a first lumen parallel to a second lumen, wherein the wall defines an opening of the first lumen adjacent to an opening of the second lumen; introducing an aerosol comprising a bioresorbable material through the opening of the second lumen into the plasma chamber and the non-thermal equilibrium plasma through the distal opening of the second lumen; and contacting tissue of the patient with reactive species emanating from the plasma and with the aerosol downstream of the outlet to form a coating on the tissue, wherein the coating is bioresorbable. ### Claim 2 (depends on 1) The method of claim 1, wherein a distal tip of the electrode is proximate the wall of the plasma chamber opposite the outlet. ### Claim 3 (depends on 1) The method of claim 1, wherein the plasma is pulsed. ### Claim 4 (depends on 1) The method of claim 1, wherein the tissue is part of a wound, and contacting the tissue with the plasma sterilizes and coagulates the wound. ### Claim 5 (depends on 1) The method of claim 1, wherein the aerosol is generated from a liquid by a nebulizer, the bioresorbable material being dissolved or dispersed in the liquid. ### Claim 6 (depends on 1) The method of claim 1, wherein the bioresorbable material comprises a protein, a nucleic acid, a lipid, a drug, a polysaccharide, a biopolymer, a biodegradable polymer, a cell, or a combination thereof. ### Claim 7 (depends on 1) The method of claim 1, wherein the bioresorbable material comprises collagen, fibrin, fibronectin, chitin, hyaluronan, chitosan, alginate, cellulose, or a combination thereof. ### Claim 8 (depends on 1) The method of claim 1, wherein the bioresorbable material comprises blood plasma or a blood platelet. ### Claim 9 (depends on 1) The method of claim 1, wherein the bioresorbable material in the coating is biologically active. ### Claim 10 (depends on 1) The method of claim 1, wherein the bioresorbable material comprises: a. a biopolymer, a biodegradable polymer, a protein, or a combination thereof; and b. an antimicrobial, an analgesic, a vasoconstrictor, or a combination thereof. ### Claim 11 A method for treating a patient, the method comprising: generating a non-thermal equilibrium plasma at a frequency between 100 kHz and 500 kHz via an electrode housed in a plasma chamber with a wall opposite an outlet exposed to ambient pressure, the wall defining a first opening containing a distal tip of the electrode and a second opening adjacent to the first opening, wherein the electrode extends through a first lumen parallel to a second lumen, the first lumen terminating at the first opening and the second lumen terminating at the second opening; introducing an aerosol comprising a bioresorbable material through the second opening into the plasma chamber and the non-thermal equilibrium plasma, such that the bioresorbable material contacts the non-thermal plasma within the plasma chamber and exits the plasma chamber with the non-thermal equilibrium plasma; and forming a coating comprising the bioresorbable material on tissue of the patient by directly contacting the tissue with the plasma and the aerosol downstream of the plasma chamber, wherein the tissue is part of a wound, wherein the coating is bioresorbable, and wherein the bioresorbable material in the coating is biologically-active. ### Claim 12 (depends on 11) The method of claim 11, wherein the coating seals the wound. ### Claim 13 (depends on 11) The method of claim 11, wherein the bioresorbable material in the coating is cross-linked. ### Claim 14 (depends on 11) The method of claim 11, wherein the plasma is pulsed.