# US 10,946,109 B2 · Polymer-type fluorescent molecule probe

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- Number: US 10,946,109 B2
- Document ID: US10946109B2
- Status: Granted
- Kind: B2
- Application number: 15/488,952
- Filed: 2017-04-17
- Published: 2017-10-05
- Granted: 2021-03-16
- Earliest claimed: 2011-09-05
- Assignees: Hiroshi Maeda
- Applicants: Hiroshi Maeda
- Inventors: Hiroshi Maeda; Makoto Hashizume; Jun Fang; Hideaki Nakamura; Haibo Qin; Steffen Hackbarth; Masaharu Murata
- Web page: https://patentgrep.com/patent/US10946109B2

## CPC

- A61K 49/0082: {micelle, e.g. phospholipidic micelle and polymeric micelle}
- A61B 1/043: {for fluorescence imaging}
- A61B 1/313: for introducing through surgical openings, e.g. laparoscopes
- A61K 41/0057: {Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent}
- A61K 41/0071: {PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines}
- A61K 47/58: obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
- A61K 49/0034: {Indocyanine green, i.e. ICG, cardiogreen}
- A61K 49/0054: {Macromolecular compounds, i.e. oligomers, polymers, dendrimers}
- A61P 35/00: Antineoplastic agents
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- G01N 21/33: using ultraviolet light (G01N21/39 takes precedence)
- G01N 21/6447: {by visual observation}
- G01N 33/575: for cancer
- G01N 33/582: {with fluorescent label}
- G01N 33/585: {with a particulate label, e.g. coloured latex}
- A61K 49/0017: {Fluorescence in vivo}
- A61K 49/0036: {Porphyrins (used in photodynamic therapy A61K41/0071 or A61K41/0076; used as targeting group or modifying agent for targeting a therapeutic compound A61K47/546)}
- A61K 49/005: {characterised by the carrier molecule carrying the fluorescent agent}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

The present invention provides a fluorescent molecular probe for efficient fluorescent detection (visualization) of tumors or for implementing fluorescent detection and photodynamic treatment, more specifically, the present invention provides a macromolecular fluorescent molecular probe for fluorescent detection of tumor, comprising a complex comprising a fluorescent molecule and a biocompatible macromolecule.

## Claims

### Claim 1

A complex comprising a fluorescent molecule and a biocompatible macromolecule,
wherein the fluorescent molecule is chlorophyll,
the biocompatible macromolecule is selected from styrene-maleic acid copolymers, styrene-maleic acid copolymers having a multiple-functionalized maleic acid side chain, and mixtures thereof,
the fluorescent molecule is non-covalently bound to the biocompatible macromolecule, and
the complex is in the form of a micelle in which the fluorescent molecule is encapsulated in the biocompatible macromolecule.

### Claim 2 (depends on 1)

A macromolecular fluorescent molecular probe for fluorescent detection of tumor, comprising the complex according to claim 1.

### Claim 3 (depends on 2)

The macromolecular fluorescent molecular probe according to claim 2, which is for fluorescent detection of tumor by using a fluorescent endoscope or a fluorescent laparoscope.

### Claim 4 (depends on 1)

The complex according to claim 1, wherein the fluorescent molecule is chlorophyll, and the biocompatible macromolecule is selected from styrene-maleic acid copolymers.

### Claim 5 (depends on 4)

A macromolecular fluorescent molecular probe for fluorescent detection of tumor, comprising the complex according to claim 4.

### Claim 6 (depends on 5)

The macromolecular fluorescent molecular probe according to claim 5, which is for fluorescent detection of tumor by using a fluorescent endoscope or a fluorescent laparoscope.