Consensus/ancestral immunogens
AssigneesDuke University, University of Alabama at Birmingham Research Foundation, Triad National Security, LLC
InventorsBarton F. Haynes, Feng Gao, Bette T. Korber, Beatrice H. Hahn, George M. Shaw, Denise L. Monti, Ying Ying Li, Julie Decker, Hua-Xin Liao
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Abstract
The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.
Claims18
A nucleic acid comprising a nucleotide sequence that encodes a group M consensus Env comprising SEQ ID NO:
- 13, or a Cons-S gp140CFI Env comprising SEQ ID NO:
- 30, or a CON-S gp140CF Env comprising SEQ ID NO:
- 36.
A nucleic acid comprising a nucleotide sequence that encodes a recombinant gp120 envelope protein, wherein the recombinant gp120 envelope protein comprises the consecutive amino acid sequence represented by amino acid numbers 30 to 503 of SEQ ID NO:
- 13.
Dependencies are inferred from the claim text.