# US 10,946,077 B2 · Cooperia vaccine

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- Number: US 10,946,077 B2
- Document ID: US10946077B2
- Status: Granted
- Kind: B2
- Application number: 16/126,536
- Filed: 2018-09-10
- Published: 2018-12-27
- Granted: 2021-03-16
- Earliest claimed: 2012-10-09
- Assignees: Universiteit Gent
- Applicants: Universiteit Gent
- Inventors: Peter Geldhof; Jimmy Borloo; Edwin Claerebout; Jozef Vercruysse
- Web page: https://patentgrep.com/patent/US10946077B2

## CPC

- A61K 39/0003: {Invertebrate antigens}
- C07K 14/4354: {from nematodes}
- A61K 38/1767: {from invertebrates}
- A61K 2039/545: {characterised by the dose, timing or administration schedule}
- A61K 2039/552: {Veterinary vaccine}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)

## Abstract

The present invention relates to nucleotide sequences encoding Cooperia antigens, as well as to recombinant DNA molecules containing such nucleotide sequences and host cells expressing these nucleotide sequences. The invention further relates to Cooperia proteins, to methods for the production of the proteins, nucleotide sequences, recombinant DNA molecules and hosts. Furthermore, the invention relates to vaccines which induce protective immunity against infection by parasitic nematodes such as species of the genus Cooperia and to methods for preparing such a vaccine.

## Claims

### Claim 1

An isolated complementary DNA (“cDNA”) nucleic acid sequence encoding a Cooperia oncophora protein or immunogenic fragment of the protein, wherein the protein or immunogenic fragment thereof comprises an amino acid sequence having a sequence identity of at least 85% to the amino acid sequence of SEQ ID NO: 1.

### Claim 2 (depends on 1)

The cDNA nucleic acid sequence according to claim 1, having at least 85% sequence identity with the nucleic acid sequence of SEQ ID NO: 2.

### Claim 3 (depends on 1)

The cDNA nucleic acid sequence according to claim 1, having at least 90% sequence identity with the nucleic acid sequence of SEQ ID NO: 2.

### Claim 4 (depends on 2)

A recombinant DNA molecule comprising the nucleic acid sequence according to claim 2 and a functionally linked promoter.

### Claim 5 (depends on 2)

A vector comprising the nucleic acid sequence according to claim 2.

### Claim 6 (depends on 5)

The vector according to claim 5, wherein the vector is chosen from a plasmid, bacteriophage, cosmid, virus, or minichromosome.

### Claim 7 (depends on 4)

A vector comprising the recombinant DNA molecule according to claim 4.

### Claim 8 (depends on 2)

A host cell comprising the nucleic acid sequence according to claim 2.

### Claim 9 (depends on 4)

A host cell comprising the recombinant DNA molecule according to claim 4.

### Claim 10 (depends on 7)

A host cell comprising the vector according to claim 7.

### Claim 11 (depends on 8)

The host cell according to claim 8, wherein the host cell is chosen from an animal cell, bacterial cell, yeast cell, insect cell, or plant cell.