# US 10,946,053 B2 · Composition containing mixed extract of mulberry and Poria cocos bark for preventing, improving or treating neurodegenerative disorders

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- Number: US 10,946,053 B2
- Document ID: US10946053B2
- Status: Granted
- Kind: B2
- Application number: 16/820,639
- Filed: 2020-03-16
- Published: 2020-09-17
- Granted: 2021-03-16
- Earliest claimed: 2014-12-19
- Assignees: NeuroBo Pharmaceuticals, Inc.
- Applicants: NeuroBo Pharmaceuticals, Inc.
- Inventors: Sang Zin Choi; Mi Won Sohn; Hyo Sang Go; Ja Young Ryu; Jin Seok Jeong; Song Hyen Choi; Eun Jin Kim; Young Woong Cho; So Young Kim
- Web page: https://patentgrep.com/patent/US10946053B2

## CPC

- A61K 36/076: Poria
- A61K 9/00: Medicinal preparations characterised by special physical form {(nuclear magnetic resonance contrast preparations or magnetic resonance imaging contrast preparations A61K49/18; preparations containing radioactive substances A61K51/12)}
- A61K 36/605: Morus (mulberry)
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention relates to a composition comprising the mixed extract of mulberry and Poria cocos peel for preventing, improving or treating neurodegenerative disorders. The mixed extract of mulberry and Poria cocos peel which is the active ingredients contained in the composition of the present invention, has a memory improving activity through inhibiting of acetylcholine esterase and a neuroprotective effects and neuron protection by inhibiting the formation of beta amyloid and tau phosphorylation and promoting NGF production. Thus, the present invention may be useful as a pharmaceutical composition for preventing or treating degenerative neurological diseases, or as a health food for the above purpose.

## Claims

### Claim 1

A method of increasing the production of nerve growth factor (NGF) in a subject having Alzheimer's Dementia, comprising administering a composition comprising an extract of a mixture which comprises (i) mulberry and (ii) Poria cocos peel to the subject, wherein the mixture is in a weight ratio of 5:1 of the mulberry to the Poria cocos peel, and wherein the composition does not comprise Poria cocos wolf and Jeokbokryeong.

### Claim 2 (depends on 1)

The method of claim 1, wherein the composition improves cognitive abilities in the subject.

### Claim 3 (depends on 1)

The method of claim 1, wherein the composition enhances memory in the subject.

### Claim 4

A method of treating or ameliorating Alzheimer's Dementia in a subject in need thereof, comprising administering a composition comprising an extract of a mixture which comprises (i) mulberry and (ii) Poria cocos peel to the subject, wherein the mixture is in a weight ratio of 5:1 of the mulberry to the Poria cocos peel, and wherein the composition does not comprise Poria cocos wolf and Jeokbokryeong.

### Claim 5

A method of decreasing the production of beta amyloid, reducing acetyl cholinesterase activity, and/or reducing tau phosphorylation in a subject having Alzheimer's Dementia comprising administering an extract of a mixture which comprises (i) mulberry and (ii) Poria cocos peel to the subject, wherein the mixture is in a weight ratio of 5:1 of the mulberry to the Poria cocos peel, and wherein the composition does not comprise Poria cocos wolf and Jeokbokryeong.

### Claim 6 (depends on 5)

The method of claim 5, wherein the composition improves cognitive abilities in the subject.

### Claim 7 (depends on 5)

The method of claim 5, wherein the composition enhances memory in the subject.