# US 10,945,979 B1 · Amino acid compositions to promote endothelial health

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- Number: US 10,945,979 B1
- Document ID: US10945979B1
- Status: Granted
- Kind: B1
- Application number: 15/841,003
- Filed: 2017-12-13
- Granted: 2021-03-16
- Earliest claimed: 2016-12-13
- Assignees: Carl Louis Schroeder
- Applicants: Carl Louis Schroeder
- Inventors: Carl Louis Schroeder
- Web page: https://patentgrep.com/patent/US10945979B1

## CPC

- A61K 31/198: Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00)
- A23K 20/10: Organic substances
- A23K 20/142: Amino acids; Derivatives thereof
- A23K 20/158: Fatty acids; Fats; Products containing oils or fats
- A23K 20/174: Vitamins
- A23K 20/24: Compounds of alkaline earth metals, e.g. magnesium
- A23L 2/60: Sweeteners
- A23L 33/175: Amino acids
- A61K 9/0056: {Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals}
- A61K 9/0095: {Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches (A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006)}
- A61K 9/48: Preparations in capsules, e.g. of gelatin, of chocolate {(A61K9/0004 takes precedence; bite capsules A61K9/0056)}
- A61K 31/185: Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids (hydroxamic acids A61K31/16; peroxy acids A61K31/327)
- A61K 31/522: having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
- A61P 9/00: Drugs for disorders of the cardiovascular system
- C12G 3/04: by mixing, e.g. for preparation of liqueurs
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23K: FODDER
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C12G: WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES (beer C12C); PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

Amino acid compositions for promoting vascular endothelial health include arginine, citrulline, and taurine. Compositions may be combined with additional ingredients to form beverages, concentrates, and non-liquid food compositions. Methods of making concentrate compositions, beverage compositions, and non-liquid food compositions are provided. Methods of administering compositions to improve endothelial health, treat endothelial dysfunction, treat sexual dysfunction, treat altitude sickness, treat decompression sickness, treat jet lag, and treat fatigue include administering compositions including arginine, citrulline, and taurine.

## Claims

### Claim 1

A method of making a beverage for increasing vasodilation, the method comprising:
blending together the following dry ingredients:
from about 5 wt. % to about 25 wt. % arginine,
from about 3 wt. % to about 20 wt. % citrulline,
from about 1 wt. % to about 15 wt. % taurine,
from about 40 wt. % to about 75 wt. % sweetener, and
from about 0.1 wt. % to about 10 wt. % other functional ingredients; and
diluting the dry ingredients with one or more liquid ingredients selected from water, carbonated water, juice, flavored soda, liquor, wine, wine cooler, malt beverage, malt liquor, and cider;
wherein the one or more liquid ingredients are present at a concentration of at least 40 wt. % of the total weight of the dry ingredients and the one or more liquid ingredients; and
mixing to produce a beverage having at least 0.38 wt. % taurine.

### Claim 2 (depends on 1)

The method of claim 1, wherein the dry ingredients are diluted with the one or more liquid ingredients at a concentration of at least 75 wt. % of the total weight of the dry ingredients and the one or more liquid ingredients.

### Claim 3 (depends on 1)

The method of claim 1, wherein the dry ingredients are diluted with carbonated water at a concentration of at least 90 wt. % of the total weight of the dry ingredients and the carbonated water.

### Claim 4 (depends on 1)

The method of claim 1, further comprising packaging the beverage in a can, bottle, carton, or box.

### Claim 5 (depends on 1)

The method of claim 1, wherein the beverage is an alcoholic beverage comprising from about 10 grams to about 18 grams of ethanol.

### Claim 6 (depends on 1)

The method of claim 1, wherein the beverage further comprises caffeine.

### Claim 7

A method of making an enhanced water beverage, the method comprising:
blending together the following dry ingredients:
from about 5 wt. % to about 25 wt. % arginine,
from about 3 wt. % to about 20 wt. % citrulline, and
from about 1 wt. % to about 15 wt. % taurine;
diluting the dry ingredients with one or more liquid ingredients selected from water, carbonated water, and flavored soda;
wherein the one or more liquid ingredients are present at a concentration of at least 40 wt. % of the total weight of the dry ingredients and the one or more liquid ingredients; and
mixing to produce an enhanced water beverage for increasing vasodilation, the enhanced water beverage having at least 0.38 wt. % taurine and at least 0.57 wt. % citrulline.

### Claim 8 (depends on 7)

The method of claim 7, wherein the dry ingredients further comprise sucrose.

### Claim 9 (depends on 7)

The method of claim 7, wherein the dry ingredients further comprise alertness aid.

### Claim 10 (depends on 7)

The method of claim 7, wherein the dry ingredients further comprise ribose.

### Claim 11 (depends on 7)

The method of claim 7, wherein the one or more liquid ingredients comprise carbonated water.

### Claim 12 (depends on 1)

The method of claim 1, wherein the sweetener is selected from the group consisting of: sucrose, glucose, fructose, coconut palm sugar, date sugar, maple syrup, agave nectar, molasses, honey, brown rice syrup, cane juice, saccharin, sucralose, aspartame, acesulfame potassium, stevia, mogroside, erythritol, xylitol, sorbitol, maltitol, mannitol and mixtures thereof.

### Claim 13 (depends on 1)

The method of claim 1, wherein the functional ingredients are selected from the group consisting of: flavoring agents, flavor enhancers, flavanols, acidulants, food acids, coloring agents, preservatives, antioxidants, alertness aids, alcohol, herbs, spices, extracts, vitamins, minerals, mineral salts, amino acids, fatty acids, juices, solid foods, and mixtures thereof.

### Claim 14 (depends on 1)

The method of claim 1, wherein the functional ingredients comprise mineral salts selected from the group consisting of: potassium, sodium, and mixtures thereof.

### Claim 15 (depends on 1)

The method of claim 1, wherein the functional ingredients comprise food acids selected from the group consisting of: malic acid, citric acid, tartaric acid, fumaric acid, lactic acid, adipic acid, calcium fumarate, phosphoric acid, succinic acid, and mixtures thereof.

### Claim 16

A method of making a beverage for increasing vasodilation, the method comprising:
blending together dry ingredients:
L arginine;
L citrulline;
taurine;
sweetener; and
other functional ingredients; and
mixing the dry ingredients with water to produce the beverage comprising:
0.75 to 2.25 wt. % L-arginine;
0.57 to 1.73 wt. % L-citrulline;
0.38 to 1.12 wt. % taurine;
up to 15.0 wt. % sweetener;
up to 25 wt. % other functional ingredients; and
54.9 to 98.3 wt. % water.

### Claim 17 (depends on 16)

The method of claim 16, wherein the sweetener comprises at least 0.1 wt. % of ribose.

### Claim 18 (depends on 17)

The method of claim 17, wherein the sweetener further comprises at least 0.1 wt. % of sucrose.

### Claim 19 (depends on 18)

The method of claim 18, wherein the other functional ingredients comprise at least 0.1 wt. % of caffeine.

### Claim 20 (depends on 17)

The method of claim 17, wherein the other functional ingredients comprise at least 0.1 wt. % of one or more B vitamins.

### Claim 21 (depends on 16)

The method of claim 16, wherein the other functional ingredients comprise at least 0.1 wt. % of alertness aids.

### Claim 22 (depends on 16)

The method of claim 16, wherein the other functional ingredients comprise at least 0.1 wt. % of citric acid.

### Claim 23 (depends on 16)

The method of claim 16, wherein the beverage comprises at least 0.8 wt. % of L-citrulline.

### Claim 24 (depends on 16)

The method of claim 16, wherein the beverage comprises at least 0.5 wt. % taurine.