# US 10,945,970 B2 · Curcumin-based compositions and methods of use thereof

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- Number: US 10,945,970 B2
- Document ID: US10945970B2
- Status: Granted
- Kind: B2
- Application number: 16/111,502
- Filed: 2018-08-24
- Published: 2018-12-20
- Granted: 2021-03-16
- Earliest claimed: 2017-03-10
- Applicants: Franco Cavaleri
- Inventors: Franco Cavaleri
- Web page: https://patentgrep.com/patent/US10945970B2

## CPC

- A61K 31/12: Ketones
- A61K 9/485: {Inorganic compounds}
- A61K 9/4858: {Organic compounds}
- A61K 9/4866: {Organic macromolecular compounds}
- A61P 3/06: Antihyperlipidemics
- A61K 36/9066: Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
- A61K 2300/00: Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Methods and compositions for increasing LDL receptor levels in a plurality of cells are disclosed. For example, the methods include providing to the cells a curcumin composition that is at least 15% curcumin II or at least 5% curcumin III, in order to increase LDL receptor levels. In addition, compositions for increasing LDL receptor levels in a plurality of cells are disclosed, which include a curcumin composition consisting of at least 15% curcumin II or at least 5% curcumin III (or combinations of such curcuminoids), along with a pharmaceutically-acceptable solvent, filler, or carrier. Still further, methods and compositions for decreasing MSK1 levels in a plurality of cells are disclosed, which involve administering a curcumin III-enriched composition to the cells.

## Claims

### Claim 1

A composition that comprises:
(a) 30-40% curcumin I;
(b) 9-11% curcumin II; and
(c) 45%-55% curcumin III, wherein the composition is formulated as a capsule, pill, tablet, granule, solution or a suspension in an aqueous or non-aqueous liquid, oil-in-water or water-in-oil emulsion, elixir, syrup, paste, or dry powder.

### Claim 2 (depends on 1)

The composition of claim 1, which comprises about 35% curcumin I, about 10% curcumin II, and about 50% curcumin III.

### Claim 3 (depends on 1)

The composition of claim 1, wherein the composition is formulated as the capsule, which further comprises hydroxypropyl methylcellulose, water, microcrystalline cellulose, magnesium stearate, and silicon dioxide.

### Claim 4

A composition that comprises:
(a) 45-55% curcumin I;
(b) 10-20% curcumin II; and
(c) 20%-40% curcumin III, wherein the composition is formulated as a capsule, pill, tablet, granule, solution or a suspension in an aqueous or non-aqueous liquid, oil-in-water or water-in-oil emulsion, elixir, syrup, paste, or dry powder.

### Claim 5 (depends on 4)

The composition of claim 4, which comprises about 50% curcumin I, about 15% curcumin II, and about 30% curcumin III.

### Claim 6 (depends on 4)

The composition of claim 4, wherein the composition is formulated as the capsule, which further comprises hydroxypropyl methylcellulose, water, microcrystalline cellulose, magnesium stearate, and silicon dioxide.

### Claim 7

A composition that comprises a curcumin extract, which is supplemented with additional (a) curcumin II, (b) curcumin III, or (c) both curcumin II and curcumin III, such that the composition comprises:
(i) at least 50% curcumin II; or
(ii) at least 50% curcumin III,
wherein the composition is formulated as a capsule, pill, tablet, granule, solution or a suspension in an aqueous or non-aqueous liquid, oil-in-water or water-in-oil emulsion, elixir, syrup, paste, or dry powder.