# US 10,945,949 B2 · Medical chewing gum comprising cannabinoid > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,945,949 B2 - Document ID: US10945949B2 - Status: Granted - Kind: B2 - Application number: 15/766,712 - Filed: 2015-10-07 - Published: 2019-02-28 - Granted: 2021-03-16 - Earliest claimed: 2015-10-07 - Assignees: NordicCan A/S - Applicants: NordicCan A/S - Inventors: Jesper Neergaard; Anayo Ogbonna - Web page: https://patentgrep.com/patent/US10945949B2 ## CPC - A61K 9/0058: {Chewing gums (non-medicinal aspects, preparing chewing gum A23G4/00; chewing gum for care of the teeth or oral cavity, e.g. with breath freshener A61Q11/00)} - A61K 9/1635: {obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates} - A61K 9/2027: {obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates} - A61K 9/2077: {Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets} - A61K 31/658: {o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol} - A61K 47/32: Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers {, poly(meth)acrylates, or polyvinyl pyrrolidone} - A61K 47/38: Cellulose; Derivatives thereof - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) ## Abstract A medical chewing gum including gum base polymers and one or more cannabinoids as an active pharmaceutical ingredient, the gum base polymers including polyvinyl acetate and vinyl laurate-vinyl acetate copolymer in an amount of more than 90% by weight of the gum base polymers, wherein the gum base polymers include 20-95% by weight of polyvinyl acetate and 5-80% by weight of vinyl laurate-vinyl acetate copolymer. ## Claims ### Claim 1 A medical chewing gum comprising gum base polymers and one or more cannabinoids as an active pharmaceutical ingredient, wherein the gum base polymers comprise polyvinyl acetate and vinyl laurate-vinyl acetate copolymer in an amount of more than 90% by weight of the gum base polymers, and the gum base polymers include 20-95% by weight of polyvinyl acetate and 5-80% by weight of vinyl laurate-vinyl acetate copolymer, wherein the chewing gum is a compressed chewing gum comprising granules with a content of gum base and extragranular chewing gum ingredients. ### Claim 2 (depends on 1) The medical chewing gum according to claim 1, wherein the total content of gum base ingredients selected from the list consisting of polyterpene resins, resins based on gum rosin, wood rosin and tall oil resin is less than 5 percent by weight of the chewing gum. ### Claim 3 (depends on 1) The medical chewing gum according to claim 1, wherein the chewing gum contains no polyterpene resins and no resins based on gum rosin, wood rosin or tall oil resin. ### Claim 4 (depends on 1) The medical chewing gum according to claim 1, wherein the one or more cannabinoids is a least partly comprised in said granules. ### Claim 5 (depends on 1) The medical chewing gum according to claim 1, the one or more cannabinoids is a least partly comprised outside the granules. ### Claim 6 (depends on 1) The medical chewing gum according to claim 1, wherein said medical chewing gum comprises gum base granules, said gum base granules comprising gum base polymers. ### Claim 7 (depends on 1) The medical chewing gum according to claim 1, wherein the one or more cannabinoids comprises THC, CBD, and salts, derivatives, analogues and homologues thereof. ### Claim 8 (depends on 1) The medical chewing gum according to claim 1, wherein said chewing gum comprises said cannabinoids in an amount of 0.1-30 mg. ### Claim 9 (depends on 1) The medical chewing gum according to claim 1, wherein the one or more cannabinoids is at least partly contained in a carrier. ### Claim 10 (depends on 1) The medical chewing gum according to claim 1, wherein the chewing gum comprises cellulose as a carrier for said one or more cannabinoids. ### Claim 11 (depends on 10) The medical chewing gum according to claim 10, wherein said carrier cellulose is or comprises microcrystalline cellulose (MCC). ### Claim 12 (depends on 10) The medical chewing gum according to claim 10, wherein said carrier cellulose is provided in the form of particles having an average particle size between 10 and 250 micrometers. ### Claim 13 (depends on 1) The medical chewing gum according to claim 1, wherein said medical chewing gum comprises one or more fillers, wherein said one or more fillers comprises cellulose. ### Claim 14 (depends on 1) The medical chewing gum according to claim 1, wherein the medical chewing gum is substantially free of natural resins. ### Claim 15 (depends on 1) The medical chewing gum according to claim 1, wherein the chewing gum comprises gum base polymers in an amount of between 15 and 80 percent by weight of the chewing gum. ### Claim 16 (depends on 1) The medical chewing gum according to claim 1, wherein the gum base polymers consist of synthetic gum base polymers. ### Claim 17 (depends on 1) The medical chewing gum according to claim 1, wherein the weight ratio between the polyvinyl acetate and the vinyl laurate-vinyl acetate copolymer is from 8:1 to 2:3. ### Claim 18 (depends on 1) The medical chewing gum according to claim 1, wherein the weight ratio between the polyvinyl acetate and the vinyl laurate-vinyl acetate copolymer is from 5:1 to 2:3. ### Claim 19 (depends on 1) The medical chewing gum according to claim 1, wherein the weight ratio between the polyvinyl acetate and the vinyl laurate-vinyl acetate copolymer is from 3:2 to 2:3. ### Claim 20 (depends on 1) The medical chewing gum according to claim 1, wherein the weight ratio between vinyl acetate monomers of the vinyl laurate-vinyl acetate copolymer and vinyl laurate monomers of the vinyl laurate-vinyl acetate copolymer is less than 90:10. ### Claim 21 (depends on 1) The medical chewing gum according to claim 1, wherein the total release of the one or more cannabinoids is increased compared to conventional extruded chewing gum. ### Claim 22 (depends on 1) The medical chewing gum according to claim 1, wherein the release rate of the one or more cannabinoids is increased compared to conventional extruded chewing gum. ### Claim 23 (depends on 1) The medical chewing gum according to claim 1, wherein initial crumbling of the gum facilitates increased total release of the one or more cannabinoids compared to conventional extruded chewing gum. ### Claim 24 A medical chewing gum comprising gum base polymers and one or more cannabinoids as an active pharmaceutical ingredient, wherein the gum base polymers constitute more than 50% by weight of the total content of gum base ingredients, the total content of gum base ingredients selected from the list consisting of polyterpene resins, resins based on gum rosin, wood rosin and tall oil resin is less than 5% by weight of the chewing gum, and the gum base polymers include 20-95% by weight of polyvinyl acetate and 5-80% by weight of vinyl laurate-vinyl acetate copolymer, wherein the chewing gum is a compressed chewing gum comprising granules with a content of gum base and extragranular chewing gum ingredients. ### Claim 25 (depends on 24) The medical chewing gum according to claim 24, wherein the gum base polymers substantially consist of synthetic gum base polymers. ### Claim 26 A medical chewing gum comprising gum base with a content of gum base polymers and one or more cannabinoids as an active pharmaceutical ingredient, wherein the gum base comprises 15-45% by weight of polyvinyl acetate and 10-30% by weight of vinyl laurate-vinyl acetate copolymer, the total content of gum base ingredients selected from the list consisting of polyterpene resins, resins based on gum rosin, wood rosin and tall oil resin is less than 5% by weight of the chewing gum, and the gum base polymers include 20-95% by weight of polyvinyl acetate and 5-80% by weight of vinyl laurate-vinyl acetate copolymer, wherein the chewing gum is a compressed chewing gum comprising granules with a content of gum base and extragranular chewing gum ingredients. ### Claim 27 (depends on 26) The medical chewing gum according to claim 26, wherein the medical chewing gum is substantially free of natural resins.