# US 10,945,945 B2 · Stabilization of cosmetic compositions comprising fish oils and hydroxylated fatty acids and/or its derivatives

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- Number: US 10,945,945 B2
- Document ID: US10945945B2
- Status: Granted
- Kind: B2
- Application number: 16/471,511
- Filed: 2017-12-12
- Published: 2019-10-31
- Granted: 2021-03-16
- Earliest claimed: 2016-12-22
- Assignees: Conopco, Inc.
- Applicants: Conopco, Inc.
- Inventors: Marina Tomashevskaia; Hasiba Bekto
- Web page: https://patentgrep.com/patent/US10945945B2

## CPC

- A61K 8/987: {of species other than mammals or birds}
- A61K 8/062: {Oil-in-water emulsions}
- A61K 8/347: {Phenols}
- A61K 8/361: {Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof}
- A61K 8/362: Polycarboxylic acids
- A61K 8/368: with carboxyl groups directly bound to carbon atoms of aromatic rings
- A61K 8/37: Esters of carboxylic acids
- A61K 8/375: {the alcohol moiety containing more than one hydroxy group}
- A61K 8/46: containing sulfur (A61K8/44 takes precedence)
- A61K 8/463: {containing sulfuric acid derivatives, e.g. sodium lauryl sulfate}
- A61K 8/55: Phosphorus compounds
- A61K 8/922: {of vegetable origin}
- A61K 8/925: {of animal origin}
- A61K 8/9789: Magnoliopsida [dicotyledons]
- A61Q 19/00: Preparations for care of the skin
- A61Q 19/08: Anti-ageing preparations
- A61K 2800/522: Antioxidants; Radical scavengers
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

Stabilized skin care compositions are described. The compositions comprise a fish oil component that yields a product of oxidation and the component is stabilized with a radical scavenger, a peroxide decomposer and hydroxylated fatty acid and/or a derivative thereof.

## Claims

### Claim 1

A composition for application to skin comprising:
(a) a component comprising an ethyl ester of fish oil that can produce, in situ, a product of oxidation, the ethyl ester of fish oil being an ethyl ester of eicosapentaenoic acid, an ethyl ester of docosohexaenoic acid or a mixture thereof;
(b) a radical scavenger comprising dibutylhydroxytoluene, pentaerythritol tetrakis (3-3,5-di-tertbutyl-4-hydroxyphenyl) propionate) or a mixture thereof;
(c) peroxide decomposer comprising didocecyl 3,3′-thiodipropionate;
(d) hydroxylated fatty acid, hydroxylated fatty acid derivative, or a mixture thereof comprising glycerol monohydroxystearate;
(e) an oil carrier comprising caprylic/capric triglyceride, high oleic sunflower seed oil, octylhydroxystearate, mineral oil, or a mixture thereof; and
(f) water,
the composition being an emulsion comprising from 0.1 to 1.5% by weight ethyl ester of fish oil.

### Claim 2 (depends on 1)

The composition according to claim 1, wherein the composition is a lotion or cream.

### Claim 3 (depends on 1)

The composition according to claim 1, wherein the radical scavenger further comprises rosemary extract, octadecyl 3-(2,5-di-tert-butyl-4-hydroxyphenyl) propionate or a mixture thereof.

### Claim 4 (depends on 3)

The composition according to claim 3, wherein the radical scavenger is present at an amount from 0.01 to 1.0% by weight.

### Claim 5 (depends on 1)

The composition according to claim 1, wherein the peroxide decomposer is present at an amount from 0.01 to 1.0% by weight.

### Claim 6 (depends on 1)

The composition according to claim 1, wherein the composition further comprises a hydroxylated fatty acid derivative which is hydroxystearyl glucoside, ethyleneglycol monohydroxystearate, glycerylmonoricinoleate, glyceryldihydroxystearate, glyceryldiricinoleate, or a mixture thereof.

### Claim 7 (depends on 1)

The composition according to claim 1, wherein the composition further comprises salicylic acid.

### Claim 8 (depends on 1)

The composition according to claim 1, wherein the composition is free of malodor when stored in a non-airless package.

### Claim 9 (depends on 1)

The composition according to claim 1, wherein the composition further comprises fragrance and is free of malodor when topically applied.

### Claim 10 (depends on 1)

The composition according to claim 1, wherein the radical scavenger is pentaerythritol tetrakis (3-3,5-di-tertbutyl-4-hydroxyphenyl) propionate).