# US 10,945,932 B2 · Prebiotic oral care compositions containing carboxylic acids

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- Number: US 10,945,932 B2
- Document ID: US10945932B2
- Status: Granted
- Kind: B2
- Application number: 15/108,098
- Filed: 2013-12-27
- Published: 2016-11-24
- Granted: 2021-03-16
- Earliest claimed: 2013-12-27
- Assignees: Colgate-Palmolive Company; Katholieke Universiteit Leuven
- Applicants: Colgate-Palmolive Company; Katholieke Universiteit Leuven; Universiteit Gent
- Inventors: Hans Stettler; Wim Teughels; Marc Quirynen; Nico Boon
- Web page: https://patentgrep.com/patent/US10945932B2

## CPC

- A61K 8/36: Carboxylic acids; Salts or anhydrides thereof
- A61K 8/362: Polycarboxylic acids
- A61K 8/365: Hydroxycarboxylic acids; Ketocarboxylic acids
- A61K 8/37: Esters of carboxylic acids
- A61K 8/44: Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K 8/442: {substituted by amido group(s)}
- A61K 8/602: {Glycosides, e.g. rutin}
- A61K 31/198: Alpha-amino acids, e.g. alanine or edetic acid [EDTA] (betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00)
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The present invention provides an oral care composition comprising a carboxylic acid of the formula (I) wherein: R1 is H, or is a substituted or unsubstituted alkyl group; and R2 is H, OH, or NH2; for use in: (a) selectively promoting, in an oral cavity: growth, metabolic activity or colonization of bacteria that have beneficial effects on oral health, relative to growth, metabolic activity or colonization of pathogenic oral bacteria; (b) selectively promoting, in an oral cavity, biofilm formation by bacteria that have beneficial effects on oral health, relative to biofilm formation by pathogenic oral bacteria; or (c) maintaining and/or re-establishing a healthy oral microflora.

## Claims

### Claim 1

An oral care composition comprising monomethyl succinate present in the composition in a concentration of from 0.01 weight % to 10 weight %, based on the weight of the oral composition; and
wherein the composition is effective for:
(a) selectively promoting, in an oral cavity: growth, metabolic activity or colonization of S. mitis bacteria that have beneficial effects on oral health, relative to growth, metabolic activity or colonization of pathogenic oral bacteria;
(b) selectively promoting, in an oral cavity, biofilm formation by S. mitis bacteria that have beneficial effects on oral health comprising S. mitis, relative to biofilm formation by pathogenic oral bacteria; or
(c) maintaining and/or re-establishing a healthy oral microbiota comprising S. mitis;
wherein the composition further comprises at least one species of bacteria that has beneficial effects on oral health.

### Claim 2 (depends on 1)

The oral care composition of claim 1, wherein the composition is a dentifrice, a toothpaste, a gel, a tooth powder, a mouthwash, a mouthrinse, a lozenge, a tablet, a spray, a gum, or a film.

### Claim 3 (depends on 1)

The oral care composition of claim 1, wherein the species of bacteria that has beneficial effects on oral health is selected from Streptococcus mitis, Streptococcus salivarius, Streptococcus sanguinis, Actinomyces viscosus, Veillonella parvula, Streptococcus gordonii, Capnocytophaga sputigena, Actinomyces naeslundii and combinations thereof.

### Claim 4 (depends on 1)

The oral care composition of claim 1, for use in preventing one or more of gingivitis, periodontitis, peri-implantitis, peri-implant mucositis, necrotizing gingivitis, necrotizing periodontitis and caries.

### Claim 5 (depends on 1)

A method of selectively promoting, in an oral cavity of a subject:
(a) growth, metabolic activity or colonization of bacteria that have beneficial effects on oral health, relative to growth, metabolic activity or colonization of pathogenic oral bacteria; or
(b) biofilm formation by bacteria that have beneficial effects on oral health, relative to biofilm formation by pathogenic oral bacteria;
the method comprising contacting an oral cavity of the subject with an oral care composition according to claim 1.

### Claim 6 (depends on 1)

A method of maintaining and/or re-establishing a healthy oral microbiota in a subject, the method comprising contacting an oral cavity of the subject with an oral care composition according to claim 1.

### Claim 7 (depends on 1)

A method of preventing one or more of gingivitis, periodontitis, peri-implantitis, peri-implant mucositis, necrotizing gingivitis, necrotizing periodontitis and caries in a subject, the method comprising contacting an oral cavity of the subject with an oral care composition according to claim 1.