# US 10,945,781 B2 · Variable phase generation and detection for radio-frequency (RF) ablation

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- Number: US 10,945,781 B2
- Document ID: US10945781B2
- Status: Granted
- Kind: B2
- Application number: 15/697,811
- Filed: 2017-09-07
- Published: 2019-03-07
- Granted: 2021-03-16
- Earliest claimed: 2017-09-07
- Assignees: Biosense Webster (Israel) Ltd.
- Applicants: Biosense Webster (Israel) Ltd.
- Inventors: Assaf Govari
- Web page: https://patentgrep.com/patent/US10945781B2

## CPC

- A61B 18/1206: {Generators therefor}
- A61B 18/1492: {having a flexible, catheter-like structure, e.g. for heart ablation (A61B18/1477 takes precedence)}
- A61B 2018/0016: {Energy applicators arranged in a two- or three dimensional array}
- A61B 2018/00654: {with individual control of each of a plurality of energy emitting elements}
- A61B 2018/00714: {Temperature}
- A61B 2018/00732: {Frequency}
- A61B 2018/0075: {Phase}
- A61B 2018/00827: {Current}
- A61B 2018/00869: {Phase}
- A61B 2018/00892: {Voltage}
- A61B 2018/124: {switching the output to different electrodes, e.g. sequentially}
- A61B 2018/1273: {including multiple generators in one device}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

A Radio Frequency (RF) ablation system includes a signal generator, control circuitry, a plurality of non-linear amplifiers, and a processor. The signal generator is configured to generate an RF signal having a given frequency. The control circuitry is configured to set phases and amplitudes of a plurality of replicas of the RF signal generated by the signal generator. The plurality of non-linear amplifiers is configured to amplify the plurality of replicas of the RF signal, and to drive a respective plurality of ablation electrodes in a patient body with the amplified replicas. The processor is configured to receive a return signal, including a superposition of the replicas sensed by a patch electrode attached to the patient body, and to adaptively adjust the phases and amplitudes of the replicas in response to the return signal, by controlling the control circuitry.

## Claims

### Claim 1

A Radio Frequency (RF) ablation system, comprising:
a signal generator disposed in a control unit outside a patient body, the signal generator configured to generate an RF signal having a given frequency;
control circuitry, configured to set phases and amplitudes of a plurality of replicas of the RF signal generated by the signal generator;
a plurality of non-linear amplifiers, configured to amplify the plurality of replicas of the RF signal, and to drive a respective plurality of ablation electrodes in a patient body with the amplified replicas, wherein each of the plurality of non-linear amplifiers is coupled to each of the plurality of ablation electrodes by wiring passing from the control unit outside the patient body to a catheter disposed inside the patient body; and
a processor, configured to receive a return signal, comprising a superposition of the replicas sensed by a patch electrode attached to the patient body, and to adaptively adjust the phases and amplitudes of the replicas in response to the return signal, by controlling the control circuitry, wherein the control circuitry is configured to maintain one or more crosstalk currents, which flow through the patient body between the ablation electrodes, within given limits by comparing the crosstalk currents values with specified limits such that if the crosstalk currents values are within predefined limits, then the amplitudes and phases are maintained else if one or more of the crosstalk currents exceed limits, then the processor recalculates the amplitudes and phases.

### Claim 2 (depends on 1)

The ablation system according to claim 1, wherein the amplifiers comprise Class-D amplifiers.

### Claim 3 (depends on 1)

The ablation system according to claim 1, and comprising a plurality of measurement circuits, configured to measure the replicas amplified by the respective plurality of amplifiers, wherein the processor is configured to adjust the phases and the amplitudes of the replicas based on the measured replicas.

### Claim 4 (depends on 1)

The ablation system according to claim 1, wherein the control circuitry is configured to adjust one or more of the plurality of amplified replicas within given limits.

### Claim 5

A method for Radio Frequency (RF) ablation, comprising:
generating an RF signal having a given frequency;
amplifying a plurality of replicas of the RF signal, and driving a plurality of ablation electrodes disposed in a patient body with the amplified replicas, using a respective plurality of non-linear amplifiers disposed in a control unit outside the patient body;
receiving a return signal, comprising a superposition of the replicas sensed by a patch electrode attached to the patient body; and
adaptively adjusting respective phases and amplitudes of the replicas in response to the return signal, wherein the adaptively adjusting respective phases and amplitudes comprises adjusting one or more crosstalk currents, which flow through the patient body between the ablation electrodes, within given limits by comparing the crosstalk currents values with specified limits such that if the crosstalk currents values are within predefined limits, then the amplitudes and phases are maintained else if one or more of the crosstalk currents exceeds limits, then the processor recalculates the amplitudes and phases.

### Claim 6 (depends on 5)

The method according to claim 5, wherein the amplifiers comprise Class-D amplifiers.

### Claim 7 (depends on 5)

The method according to claim 5, further comprising measuring the plurality of replicas amplified by the respective plurality of amplifiers, and adjusting the phases and the amplitudes of the replicas based on the measured replicas.

### Claim 8 (depends on 5)

The method according to claim 5, wherein the adaptively adjusting respective phases and amplitudes comprises adjusting one or more of the amplified replicas within given limits.