# US 10,945,694 B2 · Breast cancer diagnosis device

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- Number: US 10,945,694 B2
- Document ID: US10945694B2
- Status: Granted
- Kind: B2
- Application number: 15/743,212
- Filed: 2015-11-27
- Published: 2018-08-09
- Granted: 2021-03-16
- Earliest claimed: 2015-07-09
- Assignees: Korea Electrotechnology Research Institute; Electronics and Telecommunications Research Institute; The Asan Foundation
- Applicants: Korea Electrotechnology Research Institute; Electronics and Telecommunications Research Institute; The Asan Foundation
- Inventors: Young Wook Choi; Soo Yeol Lee; Hak Hee Kim; Du Chang Heo; Young Min Bae; Kee Hyun Kim
- Web page: https://patentgrep.com/patent/US10945694B2

## CPC

- A61B 6/5247: {combining images from an ionising-radiation diagnostic technique and a non-ionising radiation diagnostic technique, e.g. X-ray and ultrasound}
- A61B 5/0035: {adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography}
- A61B 5/0073: {by tomography, i.e. reconstruction of 3D images from 2D projections (A61B5/0066 takes precedence)}
- A61B 5/0091: {for mammography}
- A61B 5/4312: {Breast evaluation or disorder diagnosis (optical mammography A61B5/0091)}
- A61B 5/708: {Breast positioning means}
- A61B 6/025: {Tomosynthesis}
- A61B 6/0414: {with compression means}
- A61B 6/0435: {with means for imaging suspended breasts}
- A61B 6/4208: {characterised by using a particular type of detector}
- A61B 6/4417: {related to combined acquisition of different diagnostic modalities}
- A61B 6/4452: {the source unit and the detector unit being able to move relative to each other}
- A61B 6/502: {for diagnosis of breast, i.e. mammography}
- A61B 6/588: {Setting distance between source unit and detector unit}
- A61B 6/463: {characterised by displaying multiple images or images and diagnostic data on one display}
- A61B 6/466: {adapted to display 3D data}
- A61B 6/56: {Details of data transmission or power supply, e.g. use of slip rings}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

The present invention relates to a breast cancer diagnosis device. More particularly, the present invention relates to a breast cancer diagnosis device for early detection of the presence or absence of breast cancer lesions inside the breast of a diagnosis subject. The breast cancer diagnosis device includes: an X-ray diagnosis unit generating an X-ray image of a diagnosis subject; an optical diagnosis unit generating an optical transmission image of the diagnosis subject; and a transfer unit which is coupled to the X-ray diagnosis unit and the optical diagnosis unit to transfer all or part of the X-ray diagnosis unit and the optical diagnosis unit, and sequentially transfer all or part of the X-ray diagnosis unit or the optical diagnosis unit toward the diagnosis subject.

## Claims

### Claim 1

A breast cancer diagnosis device comprising:
an X-ray diagnosis unit generating an X-ray transmission image of a diagnosis subject;
an optical diagnosis unit generating an optical transmission image of the diagnosis subject;
compression pads pressing and fixing upper and lower portions of the diagnosis subject at a predetermined pressure so that the X-ray diagnosis unit and the optical diagnosis unit sequentially generate the X-ray image and the optical transmission image while the compression pads fix the diagnosis subject;
a transfer unit which is coupled to the X-ray diagnosis unit and the optical diagnosis unit to transfer all or part of the X-ray diagnosis unit and the optical diagnosis unit, and sequentially transfer all or part of the X-ray diagnosis unit or the optical diagnosis unit toward the diagnosis subject; and
a lesion determination unit for fusing the optical transmission image and the X-ray transmission image, which are sequentially photographed in a state in which the diagnosis subject is constantly fixed to generate a fusion image,
wherein the X-ray diagnosis unit comprises:
an X-ray irradiation unit generating X-rays to irradiate the X-rays onto the diagnosis subject; and
an X-ray detection unit disposed to face the X-ray irradiation unit to acquire an X-ray diagnosis image of the diagnosis subject from the X-rays, which are irradiated from the X-ray irradiation unit to pass through the diagnosis subject,
wherein the optical diagnosis unit comprises:
an optical irradiation unit irradiating light onto the diagnosis subject; and
an optical detection unit disposed to face the optical irradiation unit to acquire an optical diagnosis image of the diagnosis subject from the light, which is irradiated from the optical irradiation unit to pass through the diagnosis subject,
wherein the transfer unit comprises a horizontal transfer unit coupled to the X-ray detection unit and the optical detection unit to horizontally transfer the X-ray detection unit and the optical detection unit, and the transfer unit moves the X-ray detection unit and the optical detection unit to sequentially place the X-ray detection unit and the optical detection unit in a straight line with the diagnosis subject while the compression pads fix the diagnosis subject,
wherein the lesion determination unit generating a first three-dimensional image in a digital breast tomosynthesis (DBT) manner by synthesizing the X-ray transmission image in a filtered back projection (FBP) manner, generating a second three-dimensional image in a diffuse optical tomography (DOT) manner based on the optical transmission image, and determining whether one or more lesions exist in the diagnosis subject using the first three-dimensional image and the second three-dimensional image.

### Claim 2 (depends on 1)

The breast cancer diagnosis device of claim 1, wherein the transfer unit comprises a vertical transfer unit selectively coupled to one of the X-ray detection unit and the optical irradiation unit or the optical detection unit to vertically transfer one of the X-ray detection unit and the optical irradiation unit or the optical detection unit and thereby to approach the diagnosis subject.

### Claim 3 (depends on 1)

The breast cancer diagnosis device of claim 1, wherein the transfer unit is coupled to the X-ray detection unit and the optical irradiation unit or the optical detection unit, and the X-ray detection unit and the optical irradiation unit or the optical detection unit are disposed on the same panel.

### Claim 4 (depends on 3)

The breast cancer diagnosis device of claim 3, wherein the transfer unit sequentially transfers the X-ray detection unit and the optical irradiation unit or the optical detection unit to sequentially generate the X-ray diagnosis image and the optical diagnosis image of the diagnosis subject.

### Claim 5 (depends on 1)

The breast cancer diagnosis device of claim 1, wherein the transfer unit comprises a rotation unit allowing at least one of the X-ray diagnosis unit and the optical diagnosis unit to rotate about the diagnosis subject.

### Claim 6 (depends on 5)

The breast cancer diagnosis device of claim 5, wherein the rotation unit comprises a first rotation member disposed above the diagnosis subject to allow the X-ray irradiation unit and the optical irradiation unit or the optical detection unit to rotate about the diagnosis subject.

### Claim 7 (depends on 5)

The breast cancer diagnosis device of claim 5, wherein the rotation unit comprises a second rotation member disposed below the diagnosis subject to allow the X-ray detection unit and the optical irradiation unit or the optical detection unit to rotate about the diagnosis subject.

### Claim 8 (depends on 1)

The breast cancer diagnosis device of claim 1, wherein the compression pads comprise:
an upper plate disposed on the diagnosis subject to come into contact with the upper portion of the diagnosis subject; and
a lower plate disposed to face the upper plate and disposed on a lower portion of the diagnosis subject to come into contact with the lower portion of the diagnosis subject.

### Claim 9 (depends on 8)

The breast cancer diagnosis device of claim 8, wherein the compression pads press the diagnosis subject that is disposed between the upper plate and the lower plate through ascending and descending of at least one of the upper plate and the lower plate.

### Claim 10 (depends on 8)

The breast cancer diagnosis device of claim 8, wherein each of the compression pads is made of a material through which wavelengths of the X-rays used for the X-ray transmission image and the light used for the optical transmission image are transmitted.

### Claim 11 (depends on 8)

The breast cancer diagnosis device of claim 8, wherein one or more through-holes through which the light used for generating the optical transmission image passes are provided in the upper plate and the lower plate constituting the compression pads, and
the through-holes of the upper plate and the through-holes of the lower plate are defined in positions corresponding to each other.

### Claim 12 (depends on 1)

The breast cancer diagnosis device of claim 1, further comprising a mount unit disposed adjacent to the transfer unit so that one of the optical irradiation unit and the optical detection unit is disposed above the diagnosis subject.

### Claim 13 (depends on 12)

The breast cancer diagnosis device of claim 12, wherein the mount unit comprises:
a first mount supporting the optical irradiation unit and the optical detection unit so that the optical irradiation unit and the optical detection unit are disposed in the straight line with the diagnosis subject; and
a second mount supporting the optical irradiation unit and the optical detection unit so that the optical irradiation unit and the optical detection unit are disposed outside a region in which the X-ray diagnosis unit diagnoses the diagnosis subject.

### Claim 14 (depends on 13)

The breast cancer diagnosis device of claim 13, wherein a cable for supplying power and transmitting or receiving data is provided in the optical irradiation unit or the optical detection unit, and
a cable guide supporting the cable provided in the optical irradiation unit or the optical detection unit while moving the cable to prevent the cable from being bent or drooping to the bottom is provided.

### Claim 15 (depends on 14)

The breast cancer diagnosis device of claim 14, wherein the cable guide comprises:
a first link disposed adjacent to the transfer unit;
a second link rotatably coupled to the first link; and
a third link rotatably coupled to the second link and comprising a ring on which the cable is mounted.

### Claim 16 (depends on 1)

The breast cancer diagnosis device of claim 1, wherein the lesion determination unit comprises:
a first image generation unit generating the first three-dimensional image with respect to the diagnosis subject by using the X-ray transmission image acquired in the X-ray detection unit;
a first determination unit determining a lesion suspicious portion in the diagnosis subject by using the first three-dimensional image;
a second image generation unit generating the second three-dimensional image with respect to the diagnosis subject by using the optical transmission image acquired in the optical detection unit;
an image comparison unit comparing the lesion suspicious portion with the optical transmission image acquired in the optical detection unit; and
a second determination unit determining whether the lesions exist in the diagnosis subject by comparing the lesion suspicious portion with the second three-dimensional image, which is performed by the image comparison unit.