# US 10,945,622 B2 · System and method for assessing electrical activity using an iterative sparse technique > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,945,622 B2 - Document ID: US10945622B2 - Status: Granted - Kind: B2 - Application number: 15/684,394 - Filed: 2017-08-23 - Published: 2018-03-01 - Granted: 2021-03-16 - Earliest claimed: 2016-08-23 - Assignees: Regents of the University of Minnesota - Applicants: Regents of the University of Minnesota - Inventors: Abbas Sohrabpour; Bin He - Web page: https://patentgrep.com/patent/US10945622B2 ## CPC - A61B 5/367: Electrophysiological study [EPS], e.g. electrical activation mapping or electro-anatomical mapping - A61B 5/0036: {including treatment, e.g., using an implantable medical device, ablating, ventilating} - A61B 5/349: Detecting specific parameters of the electrocardiograph cycle - A61B 5/372: Analysis of electroencephalograms - A61B 5/742: {using visual displays (displays for heart-related electrical signals, e.g. ECG, A61B5/339)} - A61B 5/245: specially adapted for magnetoencephalographic [MEG] signals - A61B 5/4094: {Diagnosing or monitoring seizure diseases, e.g. epilepsy} - A61B 2562/04: Arrangements of multiple sensors of the same type - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract Three-dimensional electrical source imaging of electrical activity in a biological system (e.g., brain or heart) may involve sensor array recording, at multiple locations, of signals (e.g. electrical or magnetic signals) of electrical activity. An initial estimate of an underlying source is obtained. Edge sparsity is imposed on the estimated electrical activity to eliminate background activity and create clear edges between an active source and background activity. The initial estimate is iteratively reweighted and a series of subsequent optimization problems launched to converge to a more accurate estimation of the underlying source. Images depicting a spatial distribution of a source are generated based on the iteratively reweighted edge sparsity, and the time-course of activity for estimated sources generated. Iterative reweighting penalizes locations with smaller source amplitude based on solutions obtained in previous iterations, and continues until a desirable solution is obtained with clear edges. The objective approach does not require subjective thresholding. ## Claims ### Claim 1 A system for three-dimensional electrical source imaging of electrical activity in a biological system, the system comprising: a sensor array configured to record, at multiple locations, signals of electrical activity in the biological system; a processor configured to: control the sensor array to record the signals of electrical activity in the biological system; generate an initial estimate of a spatial extent of an underlying source based on the signals of electrical activity; impose edge sparsity on the initial estimate to eliminate background activity and create clear edges between an active source and background activity; iteratively reweight the edge sparsity of the initial estimate and launch a series of subsequent optimization problems to converge to a more accurate estimation of the spatial extent of the underlying source, wherein the locations having smaller source amplitude are penalized based on solutions obtained in previous iterations; generate one or more images depicting the spatial extent of the underlying source in the biological system using the iteratively reweighted edge sparsity; and generate one or more time courses of electrical activity depicting temporal dynamics of the underlying source in the biological system using the iteratively reweighted edge sparsity. ### Claim 2 (depends on 1) The system of claim 1, wherein the processor is configured to generate the one or more images without application of a subjective threshold requirement for a magnitude of an electrical activity characteristic. ### Claim 3 (depends on 1) The system of claim 1, wherein the iterative reweighting continues until a solution is obtained with clear edges from the background activity. ### Claim 4 (depends on 1) The system of claim 1, wherein the processor is configured to generate a series of images or a movie depicting spread, in time, of electrical activity, and time-course of electrical activity through the biological system. ### Claim 5 (depends on 1) The system of claim 1, wherein the processor, when imposing the edge sparsity, imposes sparsity on both a solution and a spatial gradient of the solution to estimate the spatial extent of the underlying source. ### Claim 6 (depends on 1) The system of claim 1, wherein the biological system is a brain, and wherein the sensor array is configured to record electrical signals of electrical activity in the brain of a subject. ### Claim 7 (depends on 1) The system of claim 1, wherein the biological system is a brain, and wherein the sensor array is configured to record magnetic signals of electrical activity in the brain of a subject. ### Claim 8 (depends on 1) The system of claim 1, wherein the biological system is a brain, and wherein the sensor array is configured to record both electrical and magnetic signals of electrical activity in the brain of a subject. ### Claim 9 (depends on 1) The system of claim 1, wherein the biological system is a brain with epileptic disorder, and wherein the generated source images are used to determine an epileptogenic region of the brain of a subject guiding interventions. ### Claim 10 (depends on 1) The system of claim 1, wherein the biological system is a heart, and wherein the sensor array is configured to record electrical signals of electrical activity in the heart of a subject. ### Claim 11 (depends on 1) The system of claim 1, wherein the biological system is a heart with arrhythmia, and wherein the generated source images are used to determine origins of arrhythmia and arrhythmogenetic regions of the heart of a subject. ### Claim 12 (depends on 1) The system of claim 1, wherein the generated one or more images visually depict location and extent of an electrical source at a given time. ### Claim 13 (depends on 1) The system of claim 1, wherein the processor is configured to obtain the spatial extent of the underlying source by adding an edge-sparse term into a source optimization solution. ### Claim 14 (depends on 1) The system of claim 1, wherein the processor is further configured to display the generated one or more images and their related time-course of electrical activity on a display device. ### Claim 15 A method for three-dimensional source imaging of electrical activity in a biological system, the method comprising: receiving signals of electrical activity recorded, using a sensor array, at multiple locations in the biological system; generating an initial estimate of a spatial extent of an underlying source based on the signals of electrical activity; imposing edge sparsity on the initial estimate to eliminate background activity and create clear edges between an active source and background activity; iteratively reweighting the edge sparsity of the initial estimate and launching a series of subsequent optimization problems to converge to a more accurate estimation of a spatial extent of the underlying source, wherein the locations having smaller source amplitude are penalized based on solutions obtained in previous iterations; generating one or more images depicting the spatial extent of the underlying source in the biological system using the iteratively reweighted edge sparsity; and estimating one or more time courses of electrical activity depicting temporal dynamics of the underlying source in the biological system using the iteratively reweighted edge sparsity. ### Claim 16 (depends on 15) The method of claim 15, wherein the one or more images are generated without application of a subjective threshold requirement for a magnitude of an electrical activity characteristic. ### Claim 17 (depends on 15) The method of claim 15, wherein the iterative reweighting continues until a solution is obtained with clear edges from the background activity. ### Claim 18 (depends on 15) The method of claim 15, wherein the one or more images depict spread, in time, of electrical activity, and time-course of electrical activity through the biological system. ### Claim 19 (depends on 15) The method of claim 15, wherein imposing the edge sparsity further comprises imposing sparsity on both a solution and a spatial gradient of the solution to estimate the spatial extent of the underlying source. ### Claim 20 (depends on 15) The method of claim 15, wherein the biological system is a brain, and wherein the sensor array records electrical signals of electrical activity in the brain of a subject. ### Claim 21 (depends on 15) The method of claim 15, wherein the biological system is a brain, and wherein the sensor array records magnetic signals of electrical activity in the brain of a subject. ### Claim 22 (depends on 15) The method of claim 15, wherein the biological system is a brain, and wherein the sensor array records both electrical and magnetic signals of electrical activity in the brain of a subject. ### Claim 23 (depends on 15) The method of claim 15, wherein the biological system is a brain with epileptic disorder, and wherein the generated source images are used to determine an epileptogenic region of the brain of a subject guiding interventions. ### Claim 24 (depends on 15) The method of claim 15, wherein the biological system is a heart, and wherein the sensor array records electrical signals of electrical activity in the heart of a subject. ### Claim 25 (depends on 15) The method of claim 15, wherein the biological system is a heart with arrhythmia, and wherein the generated source images are used to determine origins of arrhythmia and arrhythmogenetic regions of the heart of a subject. ### Claim 26 (depends on 15) The method of claim 15, wherein the generated one or more images visually depict location and extent of an electrical source at a given time and its related time-course of electrical activity. ### Claim 27 (depends on 15) The method of claim 15, wherein the processor is configured to obtain the spatial extent of the underlying source by adding an edge-sparse term into a source optimization solution. ### Claim 28 A non-volatile storage medium having instructions for three-dimensional source imaging of electrical activity in a biological system, wherein the instructions, when executed by a processor, are configured to: receive signals of electrical activity recorded, using a sensor array, at multiple locations in the biological system; generate an initial estimate of an underlying source; impose edge sparsity on the initial estimate to eliminate background activity and create clear edges between an active source and background activity; iteratively reweight the edge sparsity of the initial estimate and launch a series of subsequent optimization problems to converge to a more accurate estimation of a spatial extent of the underlying source, wherein the locations having smaller source amplitude are penalized based on solutions obtained in previous iterations; generate one or more images depicting the spatial extent of the underlying source in the biological system using the iteratively reweighted edge sparsity; and generate one or more time courses of electrical activity depicting temporal dynamics of the underlying source in the biological system using the iteratively reweighted edge sparsity.