# US 10,945,613 B2 · Determining arterial wall property with blood flow model > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,945,613 B2 - Document ID: US10945613B2 - Status: Granted - Kind: B2 - Application number: 15/479,465 - Filed: 2017-04-05 - Published: 2017-10-05 - Granted: 2021-03-16 - Earliest claimed: 2016-04-05 - Assignees: Siemens Healthcare GmbH - Applicants: Martin Kramer; Lucian Mihai Itu; Viorel Mihalef; Puneet Sharma - Inventors: Martin Kramer; Lucian Mihai Itu; Viorel Mihalef; Puneet Sharma - Web page: https://patentgrep.com/patent/US10945613B2 ## CPC - A61B 5/02007: {Evaluating blood vessel condition, e.g. elasticity, compliance} - A61B 5/026: Measuring blood flow {(A61B3/1233, A61B3/1241 take precedence)} - A61B 5/7278: {Artificial waveform generation or derivation, e.g. synthesizing signals from measured signals} - G16H 50/50: for simulation or modelling of medical disorders - A61B 5/022: by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers - A61B 6/504: {for diagnosis of blood vessels, e.g. by angiography} - A61B 6/507: {for determination of haemodynamic parameters, e.g. perfusion CT} - A61B 8/06: Measuring blood flow - A61B 8/488: {involving Doppler signals} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA ## Abstract An estimation of arterial wall properties is provided. A method for determining a wall property of an artery such as an aorta includes acquiring patient data and extracting physical data from the patient data. The physical data is applied to a blood flow model of the aorta to obtain an individual blood flow model. The wall property of the artery is directly or indirectly determined from the individual blood flow model. ## Claims ### Claim 1 A method for determining a wall property of an artery, the method comprising: acquiring patient data, wherein acquiring the patient data includes medical imaging; extracting physical data from the patient data; obtaining an individual blood flow model, the obtaining comprising applying the physical data to a blood flow model of the artery; determining the wall property of the artery directly or indirectly from the individual blood flow model, the wall property comprising arterial compliance, arterial elastance, or arterial compliance and arterial elastance, wherein determining the wall property comprises adapting a wall stiffness along the artery, such that a measured cross-sectional area variation of the artery acquired from the medical imaging is matched with a computed cross-sectional area variation of the artery according to the individual blood flow model; and displaying the wall property on an image of the artery, such that a condition of the artery is estimable by a physician, wherein the wall property varies spatially with geometric coordinates on the image of the artery. ### Claim 2 (depends on 1) The method of claim 1, wherein acquiring the patient data includes a non-invasive measurement. ### Claim 3 (depends on 1) The method of claim 1, wherein the physical data includes an anatomical model of the artery, blood flow data, or the anatomical model of the artery and the blood flow data. ### Claim 4 (depends on 1) The method of claim 1, wherein the blood flow model is a fluid-structure interaction blood flow model. ### Claim 5 (depends on 1) The method of claim 1, wherein the blood flow model is based on a mass conservation equation and a longitudinal momentum conservation equation, the mass conservation equation and the longitudinal momentum conservation equation both relying on a time-varying cross-sectional area and a time-varying flow-rate, and wherein the mass conservation equation and the longitudinal momentum conservation equation are coupled by a state equation. ### Claim 6 (depends on 1) The method of claim 1, wherein determining the wall property of the artery comprises directly determining a local area compliance as the wall property from the blood flow model. ### Claim 7 (depends on 1) The method of claim 1, further comprising determining a local wave speed of blood in the artery from the blood flow model, wherein determining the wall property of the artery comprises estimating the wall property from the local wave speed. ### Claim 8 (depends on 1) The method of claim 1, wherein the artery is an aorta. ### Claim 9 A device for determining a wall property of an artery, the device comprising: an acquisition device configured to acquire patient data, wherein the acquisition device is a medical imaging device, and wherein acquisition of the patient data includes medical imaging; and a processor configured to: extract physical data from the patient data; obtain an individual blood flow model, the obtainment of the individual blood flow model comprising application of the physical data to a blood flow model of the artery; determine the wall property of the artery directly or indirectly from the individual blood flow model, the wall property comprising arterial compliance, arterial elastance, or arterial compliance and arterial elastance, the determination of the wall property comprising adaptation of a wall stiffness along the artery, such that a measured cross-sectional area variation of the artery acquired from the medical imaging is matched with a computed cross-sectional area variation of the artery according to the individual blood flow model; and display the wall property on an image of the artery, such that a condition of the artery is estimable by a physician, wherein the wall property varies spatially with geometric coordinates on the image of the artery. ### Claim 10 (depends on 9) The device of claim 9, wherein the artery is an aorta. ### Claim 11 (depends on 9) The device of claim 9, wherein the acquisition of the patient data includes a non-invasive measurement. ### Claim 12 (depends on 9) The device of claim 9, wherein the physical data includes an anatomical model of the artery, blood flow data, or the anatomical model of the artery and the blood flow data. ### Claim 13 (depends on 9) The device of claim 9, wherein the blood flow model is a fluid-structure interaction blood flow model. ### Claim 14 (depends on 9) The device of claim 9, wherein the blood flow model is based on a mass conservation equation and a longitudinal momentum conservation equation, the mass conservation equation and the longitudinal momentum conservation equation both relying on a time-varying cross-sectional area and a time-varying flow-rate, and wherein the mass conservation equation and the longitudinal momentum conservation equation are coupled by a state equation.