# US 10,945,598 B2 · Method for assisting corneal severity identification using unsupervised machine learning > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,945,598 B2 - Document ID: US10945598B2 - Status: Granted - Kind: B2 - Application number: 16/269,221 - Filed: 2019-02-06 - Published: 2020-08-06 - Granted: 2021-03-16 - Earliest claimed: 2019-02-06 - Assignees: Jichi Medical University - Applicants: Jichi Medical University; Takahiko Hayashi - Inventors: Siamak Yousefi; Hidenori Takahashi; Takahiko Hayashi - Web page: https://patentgrep.com/patent/US10945598B2 ## CPC - A61B 3/107: for determining the shape or measuring the curvature of the cornea - G16H 50/20: for computer-aided diagnosis, e.g. based on medical expert systems - A61B 3/0025: {characterised by electronic signal processing, e.g. eye models} - A61B 3/1005: {for measuring distances inside the eye, e.g. thickness of the cornea (A61B3/11 takes precedence)} - A61B 3/102: {for optical coherence tomography [OCT]} - G16H 30/40: for processing medical images, e.g. editing - A61B 3/0041: {characterised by display arrangements} - G16H 50/70: for mining of medical data, e.g. analysing previous cases of other patients - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - G16H: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA ## Abstract A method for assisting corneal severity identification, the method comprising obtaining a corneal configuration data set of a cornea to be examined by a tomography such as an optical coherence tomography; visualizing the corneal configuration data set of the cornea to be examined along with a number of pre-existing corneal configuration data sets of disorder corneas, disorder-suspect corneas and normal corneas obtained by the tomography using t-distributed Stochastic Neighbor Embedding in a two or three dimensional map, and judging corneal severity from the map. ## Claims ### Claim 1 A method for assisting corneal severity identification, the method comprising: obtaining a corneal configuration data set of a cornea to be examined by a tomography; visualizing the corneal configuration data set of the cornea to be examined along with a number of pre-existing corneal configuration data sets of disorder corneas, disorder-suspect corneas and normal corneas obtained by the tomography using t-distributed Stochastic Neighbor Embedding in a two or three dimensional map, and locating a visualized part of the corneal configuration data set of the cornea to be examined on the map to judge corneal severity from a cluster which the located visualized part belongs to, wherein the cluster comprises visualized parts of the pre-existing corneal configuration data sets of disorder corneas, disorder-suspect corneas or normal corneas. ### Claim 2 (depends on 1) The method according to claim 1, wherein the tomography is an optical coherence tomography. ### Claim 3 A method for assisting corneal severity identification, the method comprising: obtaining a corneal configuration data set of a cornea to be examined by a tomography; visualizing the corneal configuration data set of the cornea to be examined along with a number of pre-existing corneal configuration data sets of disorder corneas, disorder-suspect corneas and normal corneas obtained by the tomography using t-distributed Stochastic Neighbor Embedding in a two or three dimensional map, and judging corneal severity from the map; wherein the corneal severity is at least one selected from the group consisting of keratoconus severity, bullous keratopathy severity, walleye severity, keratoleukoma severity, keratohelcosis severity, herpes corneae severity, corneal chemical burn severity, corneal thermal burn severity, and degeneratio corneae severity. ### Claim 4 A method for assisting corneal severity identification, the method comprising: obtaining a corneal configuration data set of a cornea to be examined by a tomography; visualizing the corneal configuration data set of the cornea to be examined along with a number of pre-existing corneal configuration data sets of disorder corneas, disorder-suspect corneas and normal corneas obtained by the tomography using t-distributed Stochastic Neighbor Embedding in a two or three dimensional map, and judging corneal severity from the map; wherein the corneal configuration data set comprises at least one of a 2D analysis of ACA viewing surface, a 2D analysis of CCT/ACD viewing surface, STAR360°, analysis of lens morphology on 2D Result, analysis of lens morphology on 3D Result, analysis of corneal morphology and reference point. ### Claim 5 (depends on 4) The method according to claim 4, wherein the 2D analysis of ACA viewing surface comprises at least one of AOD500, A0D750, ARA500, ARA750, TISA500, TISA750, TIA500, and TIA750. ### Claim 6 (depends on 4) The method according to claim 4, wherein the 2D analysis of CCT/ACD viewing surface comprises at least one of CCT, ACD Endo., LV, ACW, CCT, ACD[Epi.], ACD[Endo.], Vault, CLR and ATA. ### Claim 7 (depends on 4) The method according to claim 4, wherein the STAR360° comprises at least one of AOD250, AOD500, AOD750, ARA250, ARA500, ARA750, TISA250, TIA500, TIA750, CCT, ACD Endo., LV, ACW, AC.Area, IT750, IT2000, I-Curv. and ITC. ### Claim 8 (depends on 4) The method according to claim 4, wherein the analysis of lens morphology on 2D Result comprises at least one of Front R, Thickness, Diameter, Decentration and Tilt. ### Claim 9 (depends on 4) The method according to claim 4, wherein the analysis of lens morphology on 3D Result comprises at least one of Front R, Front Rs, Front Rf, Back R, Back Rs, Back Rf, Thickness, Diameter, Decentration, and Tilt. ### Claim 10 (depends on 4) The method according to claim 4, wherein the analysis of corneal morphology comprises at least one of Ks, Kf, CYL, ACCP, ECC, AA, Apex, Thinnest, and ESI. ### Claim 11 (depends on 4) The method according to claim 4, wherein the reference point comprises at least one of SS, AR, IR, IRT, and EP. ### Claim 12 A method for assisting corneal severity identification, the method comprising: obtaining a corneal configuration data set of a cornea to be examined by a tomography; visualizing the corneal configuration data set of the cornea to be examined along with a number of pre-existing corneal configuration data sets of disorder corneas, disorder-suspect corneas and normal corneas obtained by the tomography using t-distributed Stochastic Neighbor Embedding in a two or three dimensional map, and judging corneal severity from the map; wherein the corneal configuration data set comprises at least one of DSI, OSI, CSI, SD_P(4 mm), CV_P(4 mm), ACP(3 mm), RMS_E(4 mm), SR_E(4 mm), SR_H(4 mm), CSI_T, SD_T(4 mm), and CV_T(4 mm). ### Claim 13 A method for assisting corneal severity identification, the method comprising: obtaining a corneal configuration data set of a cornea to be examined by a tomography; visualizing the corneal configuration data set of the cornea to be examined along with a number of pre-existing corneal configuration data sets of disorder corneas, disorder-suspect corneas and normal corneas obtained by the tomography using t-distributed Stochastic Neighbor Embedding in a two or three dimensional map, and judging corneal severity from the map; wherein the tomography is an anterior eye part optical coherence tomography. ### Claim 14 A method for assisting corneal severity identification, the method comprising: obtaining a corneal configuration data set of a cornea to be examined by a tomography; visualizing the corneal configuration data set of the cornea to be examined along with a number of pre-existing corneal configuration data sets of disorder corneas, disorder-suspect corneas and normal corneas obtained by the tomography using t-distributed Stochastic Neighbor Embedding in a two or three dimensional map, and judging corneal severity from the map; wherein the tomography is a swept-source optical coherence tomography.