# US 10,945,446 B2 · Nutritional compositions and methods for promoting cognitive development > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,945,446 B2 - Document ID: US10945446B2 - Status: Granted - Kind: B2 - Application number: 16/776,777 - Filed: 2020-01-30 - Published: 2020-05-28 - Granted: 2021-03-16 - Earliest claimed: 2015-07-10 - Assignees: Mead Johnson Nutrition Company - Applicants: Mead Johnson Nutrition Company - Inventors: Zihua Ao; Carol Lynn Berseth; Patricia Cobb; Juan M. Gonzalez; Elisha London; Minhthy Nguyen; James David Richards; Colin Rudolph; John D. Alvey; Yadilka Maldonado; Chenzhong Kuang; Yan Xiao; Dirk Hondmann - Web page: https://patentgrep.com/patent/US10945446B2 ## CPC - A23C 17/00: Buttermilk; Buttermilk preparations (milk preparations, milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment A23C9/14; preservation of buttermilk or buttermilk preparations A23B11/50) - A23L 33/10: using additives (addition of substantially indigestible substances A23L33/21) - A23L 33/115: Fatty acids or derivatives thereof; Fats or oils - A23L 33/12: Fatty acids or derivatives thereof - A23L 33/15: Vitamins - A23L 33/17: Amino acids, peptides or proteins - A23L 33/19: Dairy proteins - A23L 33/20: Reducing nutritive value; Dietetic products with reduced nutritive value - A23L 33/21: Addition of substantially indigestible substances, e.g. dietary fibres - A23L 33/40: {Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula} - A61K 31/19: Carboxylic acids, e.g. valproic acid (salicylic acid A61K31/60) - A61K 31/202: having three or more double bonds, e.g. linolenic (eicosanoids, e.g. leukotrienes A61K31/557) - A61K 31/7004: Monosaccharides having only carbon, hydrogen and oxygen atoms - A61K 31/702: Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages - A61K 31/714: Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12 - A61K 31/715: Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters - A61K 35/20: Milk; Whey; Colostrum - A61K 38/482: {Serine endopeptidases (3.4.21)} - A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs - C12Y 304/21: Serine endopeptidases (3.4.21) - A23C: DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; PREPARATION THEREOF (preservation thereof A23B11/00) - A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B) - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION - C12Y: ENZYMES ## Abstract A method for enhancing cognitive development in a pediatric subject involving administering to the subject a nutritional composition which includes up to 7 g/100 Kcal of a fat or lipid; up to 5 g/100 Kcal of a protein or protein equivalent source; 0.25 g/100 Kcal to 16 g/100 Kcal of buttermilk; 5 mg/100 Kcal to 90 mg/100 Kcal of a source of long chain polyunsaturated fatty acid; and 0.015 g/100 Kcal to 1.5 g/100 Kcal of a prebiotic. ## Claims ### Claim 1 A nutritional composition comprising: up to 7 g/100 Kcal of a fat or lipid; up to 5 g/100 Kcal of a protein source; 0.25 g/100 Kcal to 16 g/100 Kcal of buttermilk, wherein the buttermilk comprises 6 mg/100 Kcal to 300 mg/100 Kcal of phospholipids, 1 mg/100 Kcal to 60 mg/100 Kcal of sphingomyelin, and 0.25 mg/100 Kcal to 7.5 mg/100 Kcal of gangliosides; 5 mg/100 Kcal to 90 mg/100 Kcal of a source of long chain polyunsaturated fatty acids; and a prebiotic. ### Claim 2 (depends on 1) The nutritional composition of claim 1, wherein the buttermilk is present at a level of about 0.6 g/100 Kcal to about 15 g/100 Kcal. ### Claim 3 (depends on 1) The nutritional composition of claim 1, wherein the source of long chain polyunsaturated fatty acids comprises docosahexaenoic acid. ### Claim 4 (depends on 3) The nutritional composition of claim 3, wherein the source of long chain polyunsaturated fatty acids further comprises arachidonic acid. ### Claim 5 (depends on 4) The nutritional composition of claim 4, wherein the source of long chain polyunsaturated fatty acids is present at a level of about 5 mg/100 Kcal to about 75 mg/100 Kcal. ### Claim 6 (depends on 5) The nutritional composition of claim 5, wherein the source of long chain polyunsaturated fatty acids comprises docosahexaenoic acid and arachidonic acid at a ratio of arachidonic acid to docosahexaenoic acid of about 1:3 to about 9:1. ### Claim 7 (depends on 1) The nutritional composition of claim 1, wherein the prebiotic is present at a level of about 0.015 g/100 Kcal to about 1.5 g/100 Kcal. ### Claim 8 (depends on 1) The nutritional composition of claim 1, wherein the prebiotic comprises polydextrose and galactooligosaccharides. ### Claim 9 (depends on 7) The nutritional composition of claim 7, wherein the polydextrose and galactooligosaccharides comprise at least about 20% of the prebiotic composition. ### Claim 10 (depends on 1) The nutritional composition of claim 1, wherein the nutritional composition is an infant formula. ### Claim 11 A nutritional composition comprising: up to 7 g/100 Kcal of a fat or lipid; up to 5 g/100 Kcal of a protein source; 0.25 g/100 Kcal to 16 g/100 Kcal of buttermilk, wherein the buttermilk comprises 6 mg/100 Kcal to 300 mg/100 Kcal of phospholipids, 1 mg/100 Kcal to 60 mg/100 Kcal of sphingomyelin, and 0.25 mg/100 Kcal to 7.5 mg/100 Kcal of gangliosides; 5 mg/100 Kcal to 90 mg/100 Kcal of a source of long chain polyunsaturated fatty acids; a prebiotic; and lactoferrin. ### Claim 12 (depends on 11) The nutritional composition of claim 11, wherein the buttermilk is present at a level of 0.6 g/100 Kcal to 15 g/100 Kcal. ### Claim 13 (depends on 11) The nutritional composition of claim 11, wherein the lactoferrin is present at a level of about 5 mg/100 Kcal to about 300 mg/100 Kcal. ### Claim 14 (depends on 13) The nutritional composition of claim 13, wherein the lactoferrin is from a non-human source. ### Claim 15 (depends on 11) The nutritional composition of claim 11, wherein the source of long chain polyunsaturated fatty acids comprises docosahexaenoic acid, arachidonic acid, or a combination thereof. ### Claim 16 (depends on 15) The nutritional composition of claim 15, wherein the source of long chain polyunsaturated fatty acids is present at a level of about 5 mg/100 Kcal to about 75 mg/100 Kcal. ### Claim 17 (depends on 16) The nutritional composition of claim 16, wherein the source of long chain polyunsaturated fatty acids comprises docosahexaenoic acid and arachidonic acid at a ratio of arachidonic acid to docosahexaenoic acid of about 1:3 to about 9:1. ### Claim 18 (depends on 11) The nutritional composition of claim 11, wherein the prebiotic is present at a level of about 0.015 g/100 Kcal to 1.5 g/100 Kcal. ### Claim 19 (depends on 11) The nutritional composition of claim 11, wherein the prebiotic comprises polydextrose and galactooligosaccharides. ### Claim 20 (depends on 11) The nutritional composition of claim 11, wherein the nutritional composition is an infant formula.