# US 10,945,443 B2 · Tolypocladium album strain

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- Number: US 10,945,443 B2
- Document ID: US10945443B2
- Status: Granted
- Kind: B2
- Application number: 16/141,188
- Filed: 2018-09-25
- Published: 2019-04-04
- Granted: 2021-03-16
- Earliest claimed: 2017-09-29
- Assignees: Valent BioSciences Corporation
- Applicants: Valent BioSciences LLC; Instituto Biomar, S.A.
- Inventors: Maria de los Angeles Vinuesa Navarro; Jose Maria Sanchez Lopez; Deanna Branscome; Emily E. Brazil; Rebecca Dickenson; Daniel F. Heiman; Gary T. Wang; Zuoxing Zheng; Daniel C Leep
- Web page: https://patentgrep.com/patent/US10945443B2

## CPC

- C12N 1/145: Fungi isolates
- A01N 63/30: Microbial fungi; Substances produced thereby or obtained therefrom
- C12N 1/14: Fungi (culture of mushrooms A01G18/00; as new plants A01H15/00); Culture media therefor
- C12R 2001/645: Fungi {; Processes using fungi}
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- C12R: INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS

## Abstract

A novel fungal strain of Tolypocladium album (synonym Chaunopycnis alba) is disclosed that has enhanced toxicity against insects and mites. This novel Tolypocladium album strain is capable of producing terpendoles A, C, I, J, K, N, O and P through fermentation and does not produce nalanthalide.

## Claims

### Claim 1

A pesticidal composition comprising a mixture of an effective amount of a biologically pure fungal strain of Tolypocladium album, having all the identifying characteristics of Tolypocladium album HL-105-64-AC11 having ATCC accession number PTA-124560 and a suitable carrier.

### Claim 2 (depends on 1)

A method of controlling a pest comprising applying an effective amount of the pesticidal composition of claim 1 to a pest or the pest's environment.

### Claim 3 (depends on 2)

The method of claim 2, wherein the pest is an insect.

### Claim 4 (depends on 2)

The method of claim 2, wherein the pest is an aphid.

### Claim 5 (depends on 2)

The method of claim 2, wherein the pest is a lepidopteran.

### Claim 6 (depends on 2)

The method of claim 2, wherein the pest is a thrips.

### Claim 7 (depends on 2)

The method of claim 2, where the pest is a mite.

### Claim 8 (depends on 2)

The method of claim 2, wherein the pest is a whitefly.

### Claim 9 (depends on 4)

The method of claim 4, wherein the aphid is selected from the group consisting of cotton aphid (Aphis gossypii), foxglove aphid (Aulacorthum solani), cabbage aphid (Brevicoryne brassicae), birdcherry-oat aphid (Rhopalosiphum padi) and green peach aphid (Myzus persicae).

### Claim 10 (depends on 5)

The method of claim 5, wherein the lepidopteran is selected from the group consisting of diamondback moth (Plutella xylostella) and cabbage looper (Trichoplusia ni).

### Claim 11 (depends on 6)

The method of claim 6, wherein the thrips is western flower thrips (Frankliniella occidentalis).

### Claim 12 (depends on 7)

The method of claim 7, wherein the mite is a twospotted spider mite (Tetranychus urticae).

### Claim 13 (depends on 8)

The method of claim 8, wherein the whitefly is a silverleaf whitefly (Bemesia tabaci).

### Claim 14 (depends on 1)

The composition of claim 1, wherein the composition comprises produces terpendoles A, C, I, J, K, N, O and P.

### Claim 15 (depends on 1)

The composition of claim 1, wherein the composition does not contain nalanthalide.