# US 10,945,430 B2 · Antibacterial medical product and method for producing same > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,945,430 B2 - Document ID: US10945430B2 - Status: Granted - Kind: B2 - Application number: 16/184,067 - Filed: 2018-11-08 - Published: 2019-05-02 - Granted: 2021-03-16 - Earliest claimed: 2010-07-09 - Assignees: Oerlikon Surface Solutions AG, PfäFfikon - Applicants: Oerlikon Surface Solutions AG, Pfaffikon - Inventors: Carmen Leonor Colmenares Mora; Arnd Mueller; Albert Peter Gerhard Janssen - Web page: https://patentgrep.com/patent/US10945430B2 ## CPC - A01N 25/08: containing solids as carriers or diluents - A01N 59/16: Heavy metals; Compounds thereof - A61L 27/28: Materials for coating prostheses - A61L 27/54: Biologically active materials, e.g. therapeutic substances {(A61L27/227 takes precedence)} - A61L 29/08: Materials for coatings - A61L 29/16: Biologically active materials, e.g. therapeutic substances {(A61L29/048 takes precedence)} - A61L 31/08: Materials for coatings - A61L 31/16: Biologically active materials, e.g. therapeutic substances {(A61L31/047 takes precedence)} - C23C 28/00: Coating for obtaining at least two superposed coatings either by methods not provided for in a single one of groups C23C2/00 - C23C26/00 or by combinations of methods provided for in subclasses C23C and C25C or C25D - C23C 28/321: {with at least one metal alloy layer} - C23C 28/34: {including at least one inorganic non-metallic material layer, e.g. metal carbide, nitride, boride, silicide layer and their mixtures, enamels, phosphates and sulphates} - A61L 2300/104: Silver, e.g. silver sulfadiazine - A61L 2300/404: Biocides, antimicrobial agents, antiseptic agents - A61L 2300/608: having two or more layers - A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - C23C: COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL (making metal-coated products by extrusion B21C23/22; covering with metal by connecting pre-existing layers to articles, see the relevant places, e.g. B21D39/00, B23K; metallising of glass C03C; metallising mortars, concrete, artificial stone, ceramics or natural stone C04B41/00; enamelling of, or applying a vitreous layer to, metals C23D; treating metal surfaces or coating of metals by electrolysis or electrophoresis C25D; single-crystal film growth C30B; by metallising textiles D06M11/83; decorating textiles by locally metallising D06Q1/04) ## Abstract The present invention relates to a medical product, comprising an antibacterial hard material coating, which is applied to a main body and which comprises biocide. Said hard material coating includes at least one inner layer and one outer layer, wherein the biocide concentration in the outer layer is substantially constant and greater than the biocide concentration in the inner layer and the biocide concentration in the inner layer is greater than or equal to 0.2 at %. ## Claims ### Claim 1 A method of applying a hard material coating on a main body of a medical product by a physical vapor deposition process, comprising first depositing a biocide-free material applied from a first target via arc ion plating onto the main body, and then depositing a biocide-containing material applied from a second target via magnetron sputter ion plating onto the biocide-free material, wherein the method is conducted at a temperature of less than or equal to 300° C. ### Claim 2 (depends on 1) The method of claim 1, wherein the method is conducted in an atmosphere comprising argon and nitrogen. ### Claim 3 (depends on 1) The method of claim 1, wherein the method is conducted at a pressure of 0.02 mbar. ### Claim 4 (depends on 1) The method of claim 1, further comprising depositing a bonding layer via arc ion plating on the main body prior to deposition of the hard material coating. ### Claim 5 (depends on 4) The method of claim 4, wherein the bonding layer has a thickness of less than or equal to 0.3 μm. ### Claim 6 (depends on 1) The method of claim 1, wherein the main body is subjected to mechanical or electro-chemical treatment prior to deposition of the hard material coating. ### Claim 7 (depends on 1) The method of claim 1, wherein the hard material coating comprises an inner layer and an outer layer, wherein the inner layer is between the outer layer and the main body, the outer layer has a biocide concentration (bcI) of 2 at % to 15 at %, and the inner layer has a biocide concentration (bcII) that is greater than or equal to 0.2 at % and less than bcI. ### Claim 8 (depends on 7) The method according to claim 7, wherein bcI and bcII are controlled by varying an arc current of the first target and/or by varying a sputtering power of the second target. ### Claim 9 (depends on 7) The method of claim 7, wherein the outer layer is subjected to polishing, wet blasting, and/or lapping. ### Claim 10 (depends on 1) The method of claim 1, the first target comprising titanium. ### Claim 11 (depends on 1) The method of claim 1, the second target comprising silver. ### Claim 12 (depends on 1) The method according to claim 1, wherein the hard material coating being applied comprises both biocide-free material applied from the first target via arc ion plating and biocide-containing material applied from the second target via magnetron sputter ion plating, wherein a biocide concentration in the hard material coating is controlled by varying an arc current applied to the first target and/or by varying a sputtering power applied to the second target. ### Claim 13 (depends on 12) The method according to claim 12, wherein the biocide in the biocide-containing material applied from the second target is silver.