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US 10,941,133 B2Granted
Compounds containing carbon-carbon linker as GPR120 agonists
AssigneePiramal Enterprises Limited
InventorsRajiv Sharma, Sanjay Kumar, Vishal Mahajan, Komal Bajaj, Pallavi Godse
Life of this patent
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Abstract
The present invention relates to compound of Formula (I) containing carbon-carbon linker, a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a pharmaceutically acceptable solvate, a prodrug, a polymorph, N-oxide, S-oxide, or a carboxylic acid isostere thereof; processes for their preparation; pharmaceutical compositions comprising said compounds; and their use for the treatment of the diseases or disorders mediated by GPR120 receptor.
Claims13
A compound of formula (I);
- wherein,
- Ring A and Ring C are pyridyl;
- Ring B is a (C6-C10)aryl;
- X is at least one of
- wherein represents a point of attachment;
- R is hydrogen or a (C1-C6)alkyl;
- R1, R2, and R3 at each occurrence are independently selected from the group consisting of hydrogen, a halogen, a (C1-C6)alkyl, a halo(C1-C6)alkyl, and a 3- to 10-membered cycloalkyl;
- R4 and R7 are independently selected from hydrogen and a (C1-C6)alkyl;
- R5 and R6 are independently selected from the group consisting of hydrogen, a halogen, and a (C1-C6)alkyl;
- and
- m, n and p are each an integer independently selected from 1, 2 and 3;
- wherein,
- the (C1-C6)alkyl is unsubstituted or substituted with one or more groups independently selected from the group consisting of a halogen, hydroxy, cyano, nitro, (C1-C6)alkyl, halo(C1-C6)alkyl, —O(C1-C6)alkyl, (C3-C5)cycloalkyl, and (C6-C10)aryl;
- the cycloalkyl is a 3- to 10-membered ring, which is unsubstituted or substituted with one or more groups independently selected from the group consisting of (C1-C6)alkyl, halogen, hydroxy, —O-(C1-C6)alkyl, (C3-C10)cycloalkyl, (C6-C10)aryl, amino, and cyano;
- and
- the halogen is selected from chlorine, bromine, iodine, and fluorine.
13 more elements
A compound of Formula IA;
- wherein,
- Ring A and Ring C are pyridyl;
- Ring B is a (C6-C10)aryl;
- R is hydrogen or a (C1-C6)alkyl;
- R1, R2, and R3 at each occurrence are independently selected from the group consisting of hydrogen, a halogen, a (C1-C6)alkyl, a halo(C1-C6)alkyl, and a 3- to 10-membered cycloalkyl;
- and
- m, n and p are each an integer independently selected from 1, 2 and 3;
- wherein,
- the (C1-C6)alkyl is unsubstituted or substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, cyano, nitro, (C1-C6)alkyl, halo(C1-C6)alkyl, —O(C1-C6)alkyl, (C3-C10)cycloalkyl, (C6-C10)aryl;
- the cycloalkyl is a 3- to 10-membered ring, which is unsubstituted or substituted with one or more groups independently selected from the group consisting of (C1-C6)alkyl, halogen, hydroxy, —O-(C1-C6)alkyl, (C3-C10)cycloalkyl, (C6-C10)aryl, amino, and cyano;
- and
- the halogen is selected from chlorine, bromine, iodine, and fluorine.
9 more elements
A compound of Formula IB;
- Ring A and Ring C are pyridyl;
- Ring B is a (C6-C10)aryl;
- R is hydrogen or a (C1-C6)alkyl;
- R1, R2, and R3 at each occurrence are independently selected from the group consisting of hydrogen, a halogen, a (C1-C6)alkyl, a halo(C1-C6)alkyl, and a 3- to 10-membered cycloalkyl;
- R4 is independently selected from hydrogen and a (C1-C6)alkyl;
- R5 is independently selected from hydrogen, halogen, and a (C1-C6)alkyl;
- and
- m, n and p are each an integer independently selected from 1, 2 and 3;
- wherein,
- the (C1-C6)alkyl is unsubstituted or substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, cyano, nitro, (C1-C6)alkyl, halo(C1-C6)alkyl, —O(C1-C6)alkyl, (C3-C10)cycloalkyl, and (C6-C10)aryl;
- the cycloalkyl is a 3- to 10-membered ring, which is unsubstituted or substituted with one or more groups independently selected from the group consisting of (C1-C6)alkyl, halogen, hydroxy, —O-(C1-C6)alkyl, (C3-C10)cycloalkyl, (C6-C10)aryl, amino, and cyano;
- and
- the halogen is selected from chlorine, bromine, iodine, and fluorine.
10 more elements
A compound of Formula IC;
- wherein,
- Ring A and Ring C are pyridyl;
- Ring B is a (C6-C10)aryl;
- R is hydrogen or a (C1-C6)alkyl;
- R1, R2, and R3 at each occurrence is independently selected from the group consisting of hydrogen, a halogen, a (C1-C6)alkyl, a halo(C1-C6)alkyl, and a 3- to 10-membered cycloalkyl;
- R4 and R7 are independently selected from hydrogen and a (C1-C6)alkyl;
- R5 and R6 are independently selected from the group consisting of hydrogen, a halogen, and a (C1-C6)alkyl;
- and
- m, n and p are each an integer independently selected from 1, 2 or 3;
- wherein,
- the (C1-C6)alkyl is unsubstituted or substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, cyano, nitro, (C1-C6)alkyl, halo(C1-C6)alkyl, —O(C1-C6)alkyl, (C3-C10)cycloalkyl, and (C6-C10)aryl;
- the cycloalkyl is a 3- to 10-membered ring, which is unsubstituted or substituted with one or more groups independently selected from the group consisting of (C1-C6)alkyl, halogen, hydroxy, —O-(C1-C6)alkyl, (C3-C10)cycloalkyl, (C6-C10)aryl, amino, and cyano;
- and
- the halogen is selected from chlorine, bromine, iodine, and fluorine.
11 more elements
A compound of Formula ID;
- wherein,
- Ring A and Ring C are pyridyl;
- Ring B is a (C6-C10)aryl;
- X is at least one of
- wherein represents a point of attachment;
- R is hydrogen or a (C1-C6)alkyl;
- R1, R2, and R3 at each occurrence are independently selected from the group consisting of hydrogen, a halogen, a (C1-C6)alkyl, a halo(C1-C6)alkyl, and a 3- to 10-membered cycloalkyl;
- R4 and R7 are independently selected from the group consisting of hydrogen and (C1-C6)alkyl;
- R5 and R6 are independently selected from the group consisting of hydrogen, a halogen, and a (C1-C6)alkyl;
- and
- m, n and p are each an integer independently selected from 1, 2 and 3;
- wherein,
- the (C1-C6)alkyl is unsubstituted or substituted with one or more groups independently selected from the group consisting of halogen, hydroxy, cyano, nitro, (C1-C6)alkyl, halo(C1-C6)alkyl, —O(C1-C6)alkyl, (C3-C5)cycloalkyl, and (C6-C10)aryl;
- the cycloalkyl is a 3- to 10-membered ring, which is unsubstituted or substituted with one or more groups independently selected from the group consisting of (C1-C6)alkyl, halogen, hydroxy, —O-(C1-C6)alkyl, (C3-C10)cycloalkyl, (C6-C10)aryl, amino, and cyano;
- and
- the halogen is selected from chlorine, bromine, iodine, and fluorine.
13 more elements
Dependencies are inferred from the claim text.