On-demand rapid synthesis of lomustine under continuous flow conditions
AssigneePurdue Research Foundation
InventorsDavid H Thompson, Robert Graham Cooks, Christina Ramires Ferreira, Zinia Jaman
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Abstract
Disclosed herein is a continuous manufacturing process for lomustine that has a short residence time and 63 percent yield. Major advantages of this process are that the total production cost for lomustine is lower, the product is higher quality, and the manufacturing operation is safer for production personnel.
Claims20
A method of producing Lomustine with a continuous flow condition, wherein said Lomustine is prepared using starting materials including cyclohexanamine, 1-chloro-2-isocyanatoethane, triethylamine (TEA), and optionally a solvent via a linear sequence of two chemical reactions performed separately in two telescoped flow reactors, wherein an extractor is coupled with the first telescoping reactor to remove excess starting materials from the first reaction reactor, wherein the second chemical reaction includes the step of nitrosation of an intermediate product, from the first chemical reaction, 1-(2-chloroethyl)-3-cyclohexylurea, using a nitrosation agent, wherein the nitrosation agent is sodium nitrite in formic acid or tert-butyl nitrite.
Dependencies are inferred from the claim text.