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US 10,941,098 B2Granted
Series of skin whitening (lightening) compounds
AssigneeUnigen, Inc.
InventorsSandip K. Nandy, Jiyun Liu, Alexandre Mikhailovitch Nesterov, Carmen Hertel, Abeysinghe Arrachchigae Papmapiya
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Abstract
The present invention is directed to inhibitors of tyrosinase, pharmaceutical compositions comprising such tyrosinase inhibitors, and methods of making and using the same. Specifically, included in the present invention are compositions of matter comprised of at least one 2,4-dihydroxybenzene analog, which inhibit the activity of tyrosinase and which inhibit the overproduction of melanin.
Claims7
A compound of Formula IV:
- wherein represents double or single bond;
- R1 is selected from the group consisting of H, or C1-C10 alkyl;
- R4 is selected from the group consisting of H or OH;
- and
- R5 is a selected from the group consisting of a 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-furanyl, 3-furanyl or 2-tetrahydrofuranyl;
- wherein R5 is substituted with 1 to 3 moieties (R′, R″, R′″) independently selected from the group consisting of a C1-C10 alkyl group, a C1-C10 alkoxy group or a hydroxyl group.
3 more elements
Dependencies are inferred from the claim text.