Glycotargeting therapeutics

A compound comprising Formula 1:

• XY-Z]m Formula 1
• where:
• m is an integer from 1 to 100;
• X comprises an antigen comprising one or more of SEQ ID NOs:
• 4 to 13, or
• X is selected from the group consisting of insulin, proinsulin, preproinsulin or a tolerogenic portion of any of insulin, proinsulin, or preproinsulin;
• Y comprises
• where:
• the left bracket “(” indicates the bond between X and Y;
• the bottom bracket and “)” indicates the bond between Y and Z;
• n is an integer from 1 to 100;
• p is an integer from 2 to 150;
• R8 is —CH2—CH2—C(CH3)(CN)—;
• and
• W is a copolymer or a random copolymer of the W1 and W2 having p repeat units, where:
• where:
• R9 is a direct bond, —C(O)—NH—CH2—CH2—, or —C(O)—NH—(CH2—CH2—O—)t—CH2—CH2—;
• t is an integer from 1 to 5;
• and
• R10 is an aliphatic group, an alcohol or an aliphatic alcohol;
• and
• Z comprises one or more liver-targeting moieties.