Adjuvant compositions
AssigneeZoetis Services LLC
InventorsPaul Joseph Dominowski, Ramasamy Mannar Mannan, Richard Lee Krebs, James Richard Thompson, Tedd Alan Childers, Mary Kathryn Olsen, Robert John Yancey, Jr., Risini Dhammika Weeratna, Shucheng Zhang, Cedo Martin Bagi
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Abstract
This invention relates to adjuvant formulations comprising various combinations of triterpenoids, sterols, immunomodulators, polymers, and Th2 stimulators; methods for making the adjuvant compositions; and the use of the adjuvant formulations in immunogenic and vaccine compositions with different antigens. This invention further relates to the use of the formulations in the treatment of animals.
Claims5
An adjuvant composition comprising an immunostimulatory oligonucleotide, a polyacrylic acid polymer and at least two of the following:
- a. dimethyl dioctadecyl ammonium bromide (DDA);
- b. a sterol;
- c. N-(2-deoxy-2-L-leucylamino-β-D-glucopyranosyl)-N-octadecyldodecanamide acetate.
Dependencies are inferred from the claim text.