RNA viruses for immunovirotherapy
AssigneeDeutsches Krebsforschungszentrum
InventorsChristine Engeland, Guy Ungerechts, Sascha Bossow
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Abstract
The present invention relates to a recombinant virus of the family Paramyxoviridae, comprising at least one expressible polynucleotide encoding a secreted activator of the immune response, to a polynucleotide encoding the same, and to a kit comprising the same. Moreover, the present invention relates to a method for treating cancer in a subject afflicted with cancer, comprising contacting said subject with a recombinant virus of the family Paramyxoviridae of the invention, and thereby, treating cancer in a subject afflicted with cancer.
Claims18
A polynucleotide encoding a recombinant virus of the family Paramyxoviridae, the polynucleotide comprising the nucleic acid sequence of SEQ ID NO:
- 6, 7, 8, and/or 9, wherein the recombinant virus comprises at least one expressible polynucleotide encoding a secreted activator of the immune response.
Dependencies are inferred from the claim text.