Bacteria engineered to treat a disease or disorder
AssigneeSynlogic Operating Company, Inc.
InventorsDean Falb, Paul F. Miller, Jonathan W. Kotula, Vincent M. Isabella, Suman Machinani, Adam B. Fisher, Yves Millet
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Abstract
Genetically programmed microorganisms, such as bacteria, pharmaceutical compositions thereof, and methods of modulating and treating a disease and/or disorder are disclosed.
Claims22
A recombinant non-pathogenic bacterium capable of metabolizing phenylalanine, wherein the bacterium comprises at least one heterologous gene encoding a phenylalanine transporter for importing phenylalanine into the bacterium, wherein the gene encoding the transporter is operably linked to a directly or indirectly inducible promoter that is not associated with the transporter in nature;
- wherein the bacterium further comprises at least one heterologous gene encoding a polypeptide for metabolizing phenylalanine, and wherein the gene encoding the polypeptide is operably linked to a directly or indirectly inducible promoter that is not associated with the polypeptide in nature.
A recombinant bacterium capable of metabolizing phenylalanine,
- wherein the bacterium comprises at least one heterologous gene encoding a phenylalanine transporter for importing the phenylalanine into the bacterium, wherein the gene encoding the transporter is operably linked to a directly or indirectly inducible promoter that is not associated with the transporter in nature;
- wherein the bacterium further comprises at least one heterologous gene encoding a polypeptide for metabolizing the phenylalanine, and wherein the gene encoding the polypeptide is operably linked to a directly or indirectly inducible promoter that is not associated with the polypeptide in nature;
- and
- wherein the bacterium is capable of reducing the level of the phenylalanine in an in vitro culture by about 50% as compared to a bacterium that does not comprise a heterologous gene encoding a polypeptide for metabolizing phenylalanine.
Dependencies are inferred from the claim text.