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US 10,927,354 B2Granted
D-type amino acid dehydrogenase
AssigneesKureha Corporation, National Institute of Advanced Industrial Science and Technology
InventorsHironaga Akita, Yuusuke Nakamichi, Masahiro Watanabe, Akinori Matsushika, Tomotake Morita
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Abstract
An enzyme has an activity of reversible dehydrogenation of D-amino acid and is a hexamer of polypeptides having an amino acid sequence that has 80% or more identity with the amino acid sequence of SEQ ID NO: 2. The amino acid sequence of the polypeptide can include one or more amino acid substitutions for one or more amino acid residues of SEQ ID NO: 2.
Claims12
An enzyme comprising the following characteristics of (a) and (b):
- (a) the enzyme has reversible D-amino acid dehydrogenase activity;
- and
- (b) the enzyme is a hexamer of polypeptides, wherein each of the polypeptides of the hexamer comprises an amino acid sequence having at least 90% sequence identity with the amino acid sequence of SEQ ID NO:
- 2, and wherein one or more amino acids at the positions corresponding to Asp95, Met155, Val159, Thr174, Arg184, and His230 of SEQ ID NO:
- 2 is substituted with a different amino acid in the amino acid sequence of each of the polypeptides.
2 more elements
Dependencies are inferred from the claim text.