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US 10,926,000 B2Granted
Deposition-conversion method for tunable calcium phosphate coatings on substrates and apparatus prepared thereof
AssigneeColorado School of Mines
InventorsJacqueline L. Harding, Melissa D. Krebs
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Abstract
The present invention relates to a method for in situ biomimetic mineralization of polymeric hydrogels, where the incorporated CaP phase can be selectively tuned in chemical composition and morphology to mimic bone and dental mineral. The present invention also relates to a method to coat a substrate with apatite material, the resulting product and the use of the product.
Claims20
A method of depositing calcium phosphate on a substrate, comprising:
- providing a substrate comprising one of a chitosan, a cellulose, an alginate, a collagen, or combinations thereof;
- immersing the substrate in a calcium ion solution;
- immersing the substrate in water;
- immersing the substrate into a phosphate ion solution;
- alternating the immersion of the substrate into the calcium ion solution and the phosphate ion solution to prepare a coated substrate;
- and
- tuning the coated substrate to a calcium phosphate by hydrolyzing the coated substrate in a fluid under predetermined physiological conditions to form the calcium phosphate.
4 more elements
Dependencies are inferred from the claim text.