Method of manufacturing a biocompatible composite material
AssigneeBoston Scientific Scimed, Inc.
InventorsJoseph Thomas Delaney, Jr., Patrick Willoughby, David Robert Wulfman, Andrew J. Ro, Niraj Gurung
Life of this patent
Estimating the term…
Abstract
Aspects herein relate to biocompatible polyisobutylene-fiber composite materials and related methods. In one aspect a biocompatible composite material is included. The biocompatible composite material can include a network of fibers comprising one or more polymers to form a substrate and a continuous, interpenetrating polyisobutylene matrix that is non-porous and completely surrounds the electrospun fibers. Other aspects are included herein.
Claims11
A method of manufacturing a biocompatible composite material, the method comprising:
- providing a network of electrospun fibers comprised of one or more thermoplastic polymers to form a fiber substrate;
- wherein the fiber substrate comprises a substantial number of pores;
- adsorbing to the surface of the network of electrospun fibers a flowable cross-linkable polyisobutylene composition comprising a polyisobutylene monomer, macromer, or polymer and a free radical initiator, and allowing the polyisobutylene composition to penetrate the pores;
- and
- initiating cross-linking of the polyisobutylene polymer to create a continuous, interpenetrating thermoset polyisobutylene matrix that completely surrounds the electrospun fibers;
- wherein the network of electrospun fibers is disposed throughout a thickness of the surrounding thermoset polyisobutylene matrix.
A method of manufacturing a biocompatible elastomeric composite material, the method comprising:
- providing a network of electrospun fibers comprised of one or more polymers to form a fiber substrate wherein the fiber substrate comprises a substantial number of pores;
- adsorbing to the surface of the network of electrospun fibers a flowable cross-linkable polyisobutylene composition comprising a highly reactive polyisobutylene (HR-PIB), maleic anhydride, and a free radical initiator, and allowing the polyisobutylene composition to penetrate the pores;
- and
- initiating cross-linking between the HR-PIB and maleic anhydride to form alternating PIB and maleic anhydride chains to create a continuous, interpenetrating thermoset polyisobutylene matrix that is nonporous and completely surrounds the electrospun fibers;
- and
- wherein the network of electrospun fibers is disposed throughout a thickness of the surrounding thermoset polyisobutylene matrix.
A method of manufacturing a biocompatible elastomeric composite material, the method comprising:
- providing a network of fibers comprised of one or more polymers to form a substrate;
- adsorbing to the surface of the network of fibers a cross-linkable polyisobutylene composition comprising a diallyl polyisobutylene itaconic anhydride, and a free radical initiator;
- and
- initiating cross-linking between the diallyl-PIB and itaconic anhydride to form alternating PIB and itaconic anhydride chains to create a continuous, interpenetrating thermoset polyisobutylene matrix that completely surrounds the electrospun fibers.
Dependencies are inferred from the claim text.