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US 10,925,968 B2Granted
Cell internalizing compounds
AssigneeSorrento Therapeutics, Inc.
InventorsYanwen Fu, Gunnar F. Kaufmann, Heehyoung Lee, Tong Zhu, Henry Hongjun Ji
Life of this patent
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Abstract
Provided herein are cell penetrating compounds having the Formula I: where, generally, each T is a thiol reactive group (e.g., a phosphorothioate), each L is a linker (e.g., a linear alkyl), and Y is a biologic (e.g., an antibody). Also provided are pharmaceutical compositions including the cell penetrating compounds, and methods of delivering the compound into a cell.
Claims17
A compound having the Formula II:
- or a pharmaceutically acceptable salt thereof, wherein:
- each R is CH3 or H;
- each L is independently a polyethylene glycol (PEG), a linear alkyl, or a cyclic alkyl;
- Y is a protein, an antibody, a peptide, or a nucleic acid;
- and
- n is an integer from 5 to 25.
3 more elements
Dependencies are inferred from the claim text.