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US 10,925,925 B2Granted
Therapy of atherosclerosis, primary biliary cirrhosis and NRLP3 inflammasome-associated disease by HTCP inhibitors
AssigneeMyr GmbH
InventorAlexander Alexandrov
Life of this patent
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Abstract
An inhibitor of Na+-taurocholate cotransporting polypeptide (NTCP) for use in a method of treatment of primary biliary cirrhosis, atherosclerosis, or an NRLP3 inflammasome-associated disease in a subject.
Claims18
A method for treatment of primary biliary cirrhosis in a subject in need thereof comprising administering an effective amount of a Na+-taurocholate cotransporting polypeptide (NTCP) inhibitor to the subject,
- wherein the NTCP inhibitor is a pre-S1 peptide inhibitor,
- wherein the pre-S1 peptide inhibitor comprises a peptide comprising amino acid sequence NPLGFX0P (SEQ ID NO:
- 15), and
- wherein X0 is any amino acid.
1 more element
Dependencies are inferred from the claim text.