Compositions for the treatment of pulmonary fibrosis
AssigneeVectus Biosystems Limited
InventorKaren Annette Duggan
Life of this patent
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Abstract
The present invention relates to compounds and their use in the prophylactic and/or therapeutic treatment of pulmonary fibrosis and/or related conditions.
Claims10
A compound of the formula:
- or a pharmacologically acceptable salt, stereoisomer, diastereomer, enantiomer, racemate, hydrate and/or solvate thereof,
- wherein:
- B is selected from the group consisting of:
- R1, R3 and R4 are independently C, CH, CH2, O, N, NH or S,
- R2 is C, CH, CH2, N, NH, C—CF3, CH—CF3 or C═O;
- R5 to R9 are independently C or N;
- Q is independently selected from halo, alkyl, hydroxy, amino and substituted amino;
- n is 0, 1, 2, 3, 4 or 5;
- D is:
- R10 to R14 are independently C, N, O or S;
- T is independently selected from C1-6alkyl, halo, C0-6alkyl carboxylic acid, amino, hydroxy and C1-6alkoxy;
- and
- m is 0, 1, 2, 3 or 4,
- wherein D cannot be unsubstituted phenyl, and Q cannot be hydroxy when n is 1 and R5 to R9 are all C.
A compound of the formula:
- or a pharmacologically acceptable salt, stereoisomer, diastereomer, enantiomer, racemate, hydrate and/or solvate thereof.
A method of therapeutically treating pulmonary fibrosis, or a related condition in a subject with pulmonary fibrosis or at risk of developing, the method comprising administering to the subject an effective amount of a compound of the formulae:
- or a pharmacologically acceptable salt, stereoisomer, diastereomer, enantiomer, racemate, hydrate and/or solvate thereof,
- wherein:
- D is independently selected from:
- T is independently selected from C1-6alkyl, halo, C0-6alkyl carboxylic acid, amino, hydroxy and C1-6alkoxy;
- m is 0, 1, 2, 3 or 4;
- and
- X is —OH.
A method of therapeutically treating pulmonary fibrosis, or a related condition in a subject with pulmonary fibrosis, the method comprising administering to the subject an effective amount of a compound selected from the group consisting of:
- or a pharmacologically acceptable salt, stereoisomer, diastereomer, enantiomer, racemate, hydrate and/or solvate thereof.
Dependencies are inferred from the claim text.