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US 10,919,835 B2Granted
Compounds and synthetic methods for the preparation of retinoid X receptor-specific retinoids
AssigneeIo Therapeutics, Inc.
InventorsRoshantha A. Chandraratna, Vidyasagar Pradeep Vuligonda, Thomas Jacks, Peter Wade, Andrew Thompson
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Abstract
Provided herein are compounds useful for the preparation of compounds that have retinoid-like biological activity. Also provided herein are processes for the preparation of compounds that have retinoid-like biological activity.
Claims17
A method of making Compound 38,
- or a pharmaceutically acceptable salt thereof,
- comprising a synthetic process of preparing intermediate compound 8, (Z)-3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)but-2-en-1-ol, of Formula (XII),
- or a solvate thereof,
- by reacting compound 4, sodium (5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)boronate of Formula (XVI),
- or a solvate thereof,
- with compound 7, (Z)-3-iodobut-2-en-1-ol, of Formula (XVII),
- or a solvate thereof,
- in the presence of Pd/C and a base, such that the compound of Formula (XII) or a solvate thereof is prepared.
5 more elements
A method of synthesizing compound 8, (Z)-3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)but-2-en-1-ol, of Formula (XII),
- or a solvate thereof,
- by reacting compound 4, sodium (5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)boronate of Formula (XVI),
- or a solvate thereof,
- with compound 7, (Z)-3-iodobut-2-en-1-ol, of Formula (XVII),
- or a solvate thereof,
- in the presence of Pd/C and a base, such that the compound of Formula (XII) or a solvate thereof is prepared.
3 more elements
Dependencies are inferred from the claim text.