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US 10,918,736 B2Granted
Conjugate of therapeutic enzymes
AssigneeHanmi Pharm. Co., Ltd.
InventorsDae Jin Kim, Jung Kuk Kim, Sung Youb Jung, Se Chang Kwon
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Abstract
The present invention relates to a conjugate in which an immunoglobulin Fc region is linked to therapeutic enzymes through a non-peptide polymer linkage moiety, and more specifically, to a conjugate in which a non-peptide polymer linkage moiety is specifically linked to an immunoglobulin Fc, a method of preparing the same, and a composition comprising the same.
Claims25
An enzyme conjugate, wherein a therapeutic enzyme for treating lysosomal storage disease (LSD) and an immunoglobulin Fc region are linked through a non-peptide polymer linkage moiety,
- wherein the non-peptide polymer linkage moiety is linked to the N-terminus of the immunoglobulin Fc region;
- and
- wherein the enzyme conjugate has increased bioavailability (BA) compared to the enzyme to which the immunoglobulin Fc region is not linked.
Dependencies are inferred from the claim text.