Dual mobile phase apparatus and method
AssigneeSwedish Biomimetics 3000 Limited
InventorAndrew Richard Russell Prewer
Life of this patent
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Abstract
An apparatus and system for contacting a mobile elongate solid phase, e.g. a ribbon with a flowing fluid phase, and a method for using the same in, for example solid phase synthesis. A particular apparatus comprises (i) a conduit which is of circular or non-circular transverse cross section and which defines a lumen to contain both the flowing fluid phase and the mobile elongate solid phase; (ii) fluid phase ports in communication with the lumen to allow the fluid phase to enter the lumen, flow through it and exit it; and (iii) solid phase ports in communication with the lumen to allow the mobile solid phase to enter the lumen, move through it and exit it, the apparatus being adapted to prevent fluid egress from its interior through the solid phase ports.
Claims25
A system for carrying out a heterogeneous process comprising a reaction between a reagent in a flowing liquid phase and a moving elongate solid phase or a substance bonded thereto, the system comprising:
- a treatment apparatus comprising a conduit that defines a lumen, wherein the conduit comprises:
- solid phase ports in communication with the lumen to allow a mobile solid phase to enter the lumen, move through it and exit it;
- and
- liquid phase ports in communication with the lumen to allow a liquid phase to enter the lumen as a single flowing stream of a liquid phase, flow through it as a single flowing stream of a liquid phase and exit it as a single flowing stream of a liquid phase
- further wherein the conduit is configured to contain the single flowing stream of the liquid phase and the moving elongate solid phase in mutual contact, wherein, during a treatment process, the elongate solid phase moves through the conduit in a first direction and the single flowing stream of the liquid phase flows through the conduit in a second direction, the first direction being opposite to the second direction, and wherein the single flowing stream of the liquid phase surrounds the moving elongate solid phase;
- one or more controllable elements;
- a sensor arranged to detect a parameter of the moving elongate solid phase and/or a sensor arranged to detect a parameter of the liquid phase;
- a processor adapted to be in signal communication with the sensor or sensors and with the controllable elements and programmed to control the controllable elements to alter the conditions of the treatment process to drive the reaction further to completion responsive to the sensor or sensors indicating that a reaction has not been driven sufficiently to completion.
A system for carrying out a heterogeneous process comprising washing a moving elongate solid phase with a flowing liquid phase, the system comprising:
- a treatment apparatus comprising a conduit that defines a lumen, wherein the conduit comprises:
- solid phase ports in communication with the lumen to allow a mobile solid phase to enter the lumen, move through it and exit it;
- and
- liquid phase ports in communication with the lumen to allow a liquid phase to enter the lumen as a single flowing stream of a liquid phase, flow through it as a single flowing stream of a liquid phase and exit it as a single flowing stream of a liquid phase
- further wherein the conduit is configured to contain the single flowing stream of the liquid phase and the moving elongate solid phase in mutual contact, wherein, during a treatment process, the elongate solid phase moves through the conduit in a first direction and the single flowing stream of the liquid phase flows through the conduit in a second direction, the first direction being opposite to the second direction, and wherein the single flowing stream of the liquid phase surrounds the moving elongate solid phase;
- one or more controllable elements;
- a sensor arranged to detect a parameter of the moving elongate solid phase and/or a sensor arranged to detect a parameter of the liquid phase;
- a processor adapted to be in signal communication with the sensor or sensors and with the controllable elements and programmed to control the controllable elements to improve the washing treatment process responsive to an unacceptable purity level being detected by the sensor or sensors.
Dependencies are inferred from the claim text.