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US 10,912,845 B2Granted
Treatment of retinal degeneration using gene therapy
AssigneeThe University of Manchester
InventorsRobert Lucas, Paul Bishop, Jasmina Cehajic-Kapetanovic
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Abstract
The present invention relates to an improved method of providing photoreceptor function to a cell, for example for use in the treatment of retinal degeneration. The present invention also relates to compositions and kits, in particular for use in such methods.
Claims14
A method of providing photoreceptor function to an inner retinal cell, comprising
- intraocularly administering a therapeutic composition comprising a nucleic acid vector comprising a nucleic acid sequence encoding human rhodopsin or human photopsin, wherein the nucleic acid is under control of a promoter which directs expression to the inner retinal cells;
- expressing the nucleic acid sequence in the inner retinal cell;
- and
- augmenting or restoring photoreceptor function of the retina by providing photoreceptor function to the inner retinal cell, wherein the inner retinal cell is an ON-bipolar cell or an OFF-bipolar cell, and wherein the nucleic acid vector is an adeno-associated viral (AAV) vector.
1 more element
Dependencies are inferred from the claim text.