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US 10,912,799 B2Granted
Compositions and methods for inhibition of lineage specific antigens
AssigneeThe Trustees of Columbia University in the City of New York
InventorsSiddhartha Mukherjee, Florence Borot, Abdullah Mahmood Ali
Life of this patent
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Abstract
Disclosed herein are methods of administering an agent targeting a lineage-specific cell-surface antigen and a population of hematopoietic cells that are deficient in the lineage-specific cell-surface antigen for immunotherapy of hematological malignancies.
Claims20
A method of treating a hematopoietic malignancy in a subject in need thereof, the method comprising
- (i) administering to the subject an effective amount of a population of genetically engineered human hematopoietic cells, wherein the hematopoietic cells are engineered such that they are deficient in a lineage-specific cell-surface antigen which is expressed by their naturally-occurring hematopoietic cell counterpart.
Dependencies are inferred from the claim text.