Identification of a T cell epitope of Prevotella copri that induces T cell responses in patients with Rheumatoid arthritis
AssigneeThe General Hospital Corporation
InventorsAllen C. Steere, Elise E. Drouin
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Abstract
Disclosed herein are methods of diagnosing Rheumatoid arthritis in a subject comprising determining whether the subject is immunologically reactive with P. copri or a portion thereof. In one aspect of the invention the immunological reactivity of the subject to one or more protein of P. copri or polypeptide fragments thereof such as protein Pc-p27 or polypeptide fragments thereof, as compared to an appropriate control, indicates the subject has rheumatoid arthritis. Examples of specific assays and kits for use with the methods are also disclosed.
Claims14
A method of treating Rheumatoid arthritis in a subject, the method comprising:
- (a) receiving the results of an assay that indicates that the subject is immunologically reactive with one or more Prevotella copri polypeptides comprising an amino acid sequence selected from the group consisting of:
- SEQ ID NO:
- 1, KRIILILTVLLAMLGQVAY (SEQ ID NO:
- 2), DYRGYWTMRYQFDSATVS (SEQ ID NO:
- 3), and EKINSLPTSSTGI (SEQ ID NO:
- 4);
- and then
- (b) administering to the subject a therapeutically effective amount of a disease modifying anti-rheumatic drug (DMARD).
Dependencies are inferred from the claim text.