Methods of treating cancer by inhibition of DNA repair proteins using antisense based therapies
AssigneeSarissa Inc.
InventorsMark D. Vincent, Peter Ferguson, D. James Koropatnick, Mateusz Rytelewski
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Abstract
Methods of treating cancer using antisense based therapies including antisense oligonucleotides of si RNAs directed against DNA double-strand break repair proteins such as BRCA2 or RAD51 are provided. The antisense based therapies can be used alone, in tandem or in combination with other cancer therapies, in particular with therapies that lead to DNA damage, inhibition of DNA repair or inhibition of DNA synthesis, such as radiation, platinum drugs, alkylating agents, PARP inhibitors, or inhibitors of thymidylate synthase.
Claims17
A method of treating cancer in a subject comprising administering to the subject an effective amount of an antisense based therapy comprising a sequence complementary to an mRNA encoding BRCA2 and a PARP-1 inhibitor;
- wherein the PARP-1 inhibitor is olaparib and the cancer has innate olaparib resistance.
A method of treating cancer in a subject, the method comprising administering to the subject an effective amount of an antisense based therapy comprising a sequence complementary to an mRNA encoding BRCA2 and a PARP-1 inhibitor;
- wherein the cancer has acquired resistance to the PARP1 inhibitor.
Dependencies are inferred from the claim text.