Rep protein for use in a diagnostic assay
AssigneeDeutsches Krebsforschungszentrum
InventorsTimo Bund, Ethel-Michele De Villiers-Zur Hausen, Harald Zur Hausen
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Abstract
The present invention concerns a DNA-replication-associated (Rep) protein comprising an amino acid sequence as depicted in SEQ ID NO: 11 or 12; (b) a fragment of SEQ ID NOs:11 or 12 which is capable of binding an anti-Rep antibody specific for a protein having the amino acid sequence of SEQ ID NOs: 11 or 12; or (c) an amino acid sequence having a 90% or more homology to the amino acid sequence of (a) or (b) and is capable of binding an anti-Rep antibody specific for a protein having an amino acid sequence of SEQ ID NOs:11 or 12. The present invention further concerns a method of diagnosing MS or a predisposition for MS and a kit for use in such methods.
Claims10
A DNA-replication-associated (Rep) protein comprising the amino acid sequence of SEQ ID NOs:
- 11 or 12.
A kit for use in the diagnosis of MS comprising:
- (a) a Rep protein, wherein the Rep protein comprises the amino acid sequence of SEQ ID NO:11 or 12;
- (b) an anti-human antibody coupled to a detectable label and capable of binding to anti-Rep antibody with a specificity for a protein having the amino acid sequence of SEQ ID NO:
- 11 or 12, and
- (c) a solid matrix suitable for immobilizing a Rep protein according to (a).
Dependencies are inferred from the claim text.