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US 10,907,138 B2Granted
TATk-CDKL5 fusion proteins, compositions, formulations, and use thereof
AssigneeAlma Mater Studiorum - Università di Bologna
InventorsElisabetta Ciani, Franco Laccone
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Abstract
Disclosed herein are compositions and formulations containing a TATk-CDKL5 fusion protein. Also disclosed are methods of producing a TATk-CDKL5 fusion protein from vectors containing a TATk-CDKL5 cDNA and methods of transducing cells with the vectors containing a TATk-CDKL5 cDNA and the TATk-CDKL5 fusion protein.
Claims16
A recombinant nucleic acid comprising:
- a CDKL5 nucleic acid sequence, wherein the CDKL5 nucleic acid sequence encodes a CDKL5 polypeptide sequence, wherein the CDKL5 polypeptide sequence comprises SEQ ID NO:
- 2 or SEQ ID NO:
- 16;
- and
- a TATk nucleic acid sequence, wherein the TATk nucleic acid sequence encodes a TATk polypeptide sequence, wherein the TATk polypeptide sequence has 90% to 100% sequence identity to SEQ ID NO:
- 4 and wherein the TATk nucleic acid sequence is operatively coupled to the CDKL5 nucleic acid sequence and/or the TATk polypeptide sequence is operatively coupled to the CDKL5 polypeptide sequence.
3 more elements
Dependencies are inferred from the claim text.