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AssigneesRiken, Kyowa Kirin Co., Ltd.
InventorsKensaku Sakamoto, Kazumasa Ohtake, Yoshimi Yamaguchi, Shigeyuki Yokoyama, Tatsuo Yanagisawa, Akiko Matsumoto, Akifumi Kato, Yasuhisa Shiraishi, Kaname Kimura, Masakazu Homma
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The present invention relates to a monoclonal antibody or antibody fragment thereof as a human IgG antibody including at least one lysine derivative in a constant region of the human IgG antibody; a modified antibody or antibody fragment thereof, wherein the lysine derivative is modified; a nucleic acid including a nucleotide sequence encoding the antibody or antibody fragment thereof; a vector including the nucleic acid; a transformed cell obtained by introducing the vector into a host cell; a method for producing the antibody or antibody fragment thereof; and a composition containing the antibody or antibody fragment thereof.
A monoclonal IgG antibody or antigen-binding fragment thereof, wherein in said monoclonal antibody or antigen-binding fragment thereof, at least one amino acid residue selected from the group consisting of amino acid residues at positions 131, 177, and 199 of a heavy chain of a human IgG antibody and amino acid residues at positions 155, 191, and 197 of a κ chain of a human antibody according to the EU-index numbering is a Z-lysine derivative.
A monoclonal IgG antibody or antigen-binding fragment thereof comprising at least one lysine derivative selected from the group consisting of N6-(((trans-cyclooct-2-en-1-yl)oxy)carbonyl)-L-lysine (hereinafter, abbreviated as “TCO*-Lys”) and N6-((bicyclo[6.1.0]non-4-yn-9-ylmethoxy)carbonyl)-L-lysine (hereinafter, abbreviated as “BCN-Lys”) in a constant region of the antibody or antigen-binding fragment thereof,
Dependencies are inferred from the claim text.