ADO-resistant cysteamine analogs and uses thereof

A method of treating a patient suffering from Huntington's Disease, Parkinson's Disease, concussion, stroke, and traumatic brain injury (CTE) comprising administering to the patient an effective amount of a composition comprising a compound of formula I or a disulfide thereof, wherein the compound of formula I is selected from the group consisting of:

• wherein:
• R1 and R2 are independently selected from the group consisting of H and C1-5alkyl;
• or
• R1 and R2, taken together with the carbon atom to which they are attached, form a 3-, 4-, 5-, 6-, 7-, or 8-membered carbocyclic ring;
• R3 and R4 are independently selected from the group consisting of H and C1-5alkyl;
• or
• R3 and R4, taken together with the carbon atom to which they are attached, form a 3-, 4-, 5-, 6-, 7-, or 8-membered carbocyclic ring;
• G is selected from the group consisting of —NR5R6 and —CR7R8NR5R6;
• R5 and R6 are independently selected from the group consisting of H and C1-5alkyl;
• or
• R5 and R6, taken together with the nitrogen atom to which they are attached, form a 3-, 4-, 5-, 6-, 7-, or 8-membered heterocyclic ring;
• R7 and R8 are independently selected from the group consisting of H and C1-5alkyl;
• or
• R7 and R8, taken together with the carbon atom to which they are attached, form a 3-, 4-, 5-, 6-, 7-, or 8-membered carbocyclic ring;
• R2 and R6, taken together with the atoms to which they are attached, form a 4-, 5-, 6-, 7-, 8-, 9-, or 10-membered heterocyclic ring;
• R4 and R6, taken together with the atoms to which they are attached, form a 4-, 5-, 6-, 7-, 8-, 9-, or 10-membered heterocyclic ring;
• R2 and R8, taken together with the atoms to which they are attached, form a 3-, 4-, 5-, 6-, 7-, or 8-membered carbocyclic ring;
• or
• R2 and R4, taken together with the atoms to which they are attached, form a 3-, 4-, 5-, 6-, 7-, or 8-membered carbocyclic ring;
• with the proviso that when G is —NH2, at least one of R1, R2, R3, and R4 is other than H.