Nitroalkene non steroidal anti-inflammatory drugs (NA-NSAIDS) and methods of treating inflammation related conditions
AssigneesInstitut Pasteur de Montevideo, Universidad de la República, Carlos Batthány
InventorsCarlos Batthyány, Gloria Virginia López, Carlos Escande, Jorge Rodriguez Duarte, Williams Arturo Porcal Quinta, Rosina Dapueto Capuccio, Germán Adrian Galliussi López, María Pia Garat Nuñez, Paulina Invernizzi, Mariana Ingold, Lucia Colella
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Abstract
Nitroalkene non-steroidal anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of treating inflammation related conditions.
Claims4
A method of treating chronic inflammation comprising administering to a subject in need thereof a therapeutically effective amount of a nitroalkene nonsteroidal anti-inflammatory drug (NA-NSAID) selected from the group consisting of:
- a compound of Formula I:
- wherein R is hydrogen or a C1-11 alkyl, or a pharmaceutically acceptable salt thereof;
- a compound of Formula II:
- wherein R is hydrogen or a C1-11 alkyl, or a pharmaceutically acceptable salt thereof;
- a compound of Formula III:
- wherein R is hydrogen or a C1-11 alkyl, or a pharmaceutically acceptable salt thereof;
- a compound of Formula V:
- wherein R is hydrogen, or a pharmaceutically acceptable salt thereof;
- and any combination thereof.
A method of treating chronic inflammation comprising administering to a subject in need thereof a pharmaceutical composition comprising a therapeutically effective amount of a nitroalkene nonsteroidal anti-inflammatory drug (NA-NSAID) selected from the group consisting of:
- a compound of Formula I:
- wherein R is hydrogen or a C1-11 alkyl, or a pharmaceutically acceptable salt thereof;
- a compound of Formula II:
- wherein R is hydrogen or a C1-11 alkyl, or a pharmaceutically acceptable salt thereof;
- a compound of Formula III:
- wherein R is hydrogen or a C1-11 alkyl, or a pharmaceutically acceptable salt thereof;
- a compound of Formula V:
- wherein R is hydrogen, or a pharmaceutically acceptable salt thereof, and any combination thereof;
- and a carrier.
Dependencies are inferred from the claim text.