Synthesis and application of chiral substituted polyvinylpyrrolidinones
AssigneeKansas State University Research Foundation
InventorDuy H. Hua
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Abstract
Chiral polyvinylpyrrolidinone (CSPVP), complexes of CSPVP with a core species, such as a metallic nanocluster catalyst, and enantioselective oxidation reactions utilizing such complexes are disclosed. The CSPVP complexes can be used in asymmetric oxidation of diols, enantioselective oxidation of alkenes, and carbon-carbon bond forming reactions, for example. The CSPVP can also be complexed with biomolecules such as proteins, DNA, and RNA, and used as nanocarriers for siRNA or dsRNA delivery.
Claims23
A chiral substituted polyvinylpyrrolidinone compound having the formula
- wherein one of R1 and R2 comprises a functional group having at least 1 carbon atom selected from the group consisting of alcohols, ethers, aliphatic hydrocarbons, aromatic hydrocarbons, and combinations thereof, and the other of R1 and R2 is H or OH, and n is greater than 100.
A chiral substituted polyvinylpyrrolidinone compound comprising an acetonide moiety attached to the pyrrolidine ring.
Dependencies are inferred from the claim text.