Methods and compositions for the repair and replacement of connective tissue

A method of repairing or replacing a damaged connective tissue, comprising the steps of:

• contacting the damaged connective tissue with a multi-layer biological construct, the multi-layer biological construct comprising
• at least one bottom layer;
• at least one top layer;
• and
• a flowable morselized layer formulated as a hydrogel and located between each of the bottom and top layers, the flowable morselized layer comprising amniotic fluid and at least one morselized human birth tissue component, and
• wherein each of the bottom layer and top layer comprise one of the following:
• at least one chemically dehydrated amniotic membrane, at least one chemically dehydrated chorionic membrane, at least one of both a chemically dehydrated amniotic and chemically dehydrated chorionic membrane, at least one cross-linked amniotic membrane, at least one cross-linked chorionic membrane, and at least one of both a cross-linked amniotic and cross-linked chorionic membrane.