Compositions and methods for treatment of pre-cancerous skin lesions
OwnerLynn Cornelius, Shadmehr Demehri +1inventors
InventorsLynn Cornelius, Shadmehr Demehri, Raphael Kopan
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Abstract
The present disclosure encompasses compositions and methods for the treatment of precancerous skin lesions. Compositions of the invention comprise a cytotoxic agent and a thymic stromal lymphopoietin (TSLP) inducer.
Claims5
A method to treat actinic keratosis in a subject in need thereof, the method comprising topically administering to the subject a composition comprising about 2% to about 5% (wt/wt) 5-fluorouracil (5-FU) and a thymic stromal lymphopoietin (TSLP) inducer, wherein the TSLP inducer is about 0.002% to about 0.005% (wt/wt) calcipotriol.
A method to prevent the transition of a precancerous skin lesion to skin cancer in a subject in need thereof, the method comprising:
- a) identifying a subject with one or more precancerous skin lesion(s);
- and
- b) topically administering to the precancerous skin lesion(s) a composition comprising about 2% to about 5% (wt/wt) 5-fluorouracil (5-FU) and a thymic stromal lymphopoietin (TSLP) inducer, wherein the TSLP inducer is about 0.002% to about 0.005% (wt/wt) calcipotriol.
Dependencies are inferred from the claim text.