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US 10,905,760 B2Granted
Chimeric hepatitis D virus antigen and hepatitis B virus pre S1 genes for use alone or in vaccines containing hepatitis B virus genes
AssigneeSvenska Vaccinfabriken Produktion AB
InventorsMatti Sällberg, Lars Frelin
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Abstract
Disclosed herein are chimeric genes, compositions of chimeric genes, and compositions of polypeptides that are useful for the generation, enhancement, or improvement of an immune response to a target antigen. Some embodiments of the compositions include chimeric genes encoding hepatitis D antigen (HDAg) protein in combination with one or more self-cleavage 2A polypeptides and a preS 1 polypeptide. In certain embodiments the self-cleavage polypeptide is P2A.
Claims24
A chimeric gene comprising in sequential order:
- a nucleic acid construct encoding a hepatitis D antigen genotype 1 A (HDAg gt1 A) domain, a hepatitis B virus PreS1 A (PreS1 A) or a hepatitis B virus PreS1 B (PreS1 B) domain or both, a porcine teschovirus-1 2A (P2A) domain, a hepatitis D antigen genotype 1 B (HDAg gt1 B) domain, a second PreS1 A or PreS1 B domain or both, and a second P2A domain.
Dependencies are inferred from the claim text.