Targeted self-assembly of functionalized carbon nanotubes on tumors
OwnerDavid A. Scheinberg, Michael R. McDevitt +2inventors
InventorsDavid A. Scheinberg, Michael R. McDevitt, Carlos H. Villa, J. Justin Mulvey
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Abstract
Provided herein is the two component self-assembly single wall nanotube system and the single wall nanotube construct that is the second component. The two component self-assembly single wall nanotube system has a morpholino oligonucleotide with a targeting moiety followed by a single wall nanotube construct with second morpholino oligonucleotides complementary to the first morpholino oligonucleotides and one or both of a therapeutic or diagnostic payload molecule linked to the single wall nanotube construct.
Claims7
A self-assembly single wall nanotube system, comprising:
- a first component having a morpholino oligonucleotide consisting of SEQ ID NO:
- 1 linked to a monoclonal antibody selective for a cancer cell;
- and
- a second component having a plurality of morpholino oligonucleotides each consisting of SEQ ID NO:
- 2 complementary to the morpholino oligonucleotide consisting of SEQ ID NO:
- 1 and a plurality of therapeutic radionuclides each independently linked to the single wall nanotube.
Dependencies are inferred from the claim text.