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US 10,899,800 B2Granted
Stabilized soluble pre-fusion RSV F polypeptides
AssigneeJanssen Vaccines & Prevention B.V.
InventorsJohannes Petrus Maria Langedijk, Anders Krarup
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Abstract
Described are stable pre-fusion respiratory syncitial virus (RSV) F polypeptides, immunogenic compositions comprising the polypeptides and uses thereof for the prevention and/or treatment of RSV infection.
Claims38
A recombinant pre-fusion respiratory syncytial virus (RSV) Fusion (F) mutant polypeptide, comprising
- a mutation of the amino acid residue N/T at position 67 into I and/or a mutation of the amino acid residue S at position 215 into P, wherein the amino acid positions are given in reference to the sequence of RSV F protein from the A2 strain (SEQ ID NO:
- 1).
Dependencies are inferred from the claim text.