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US 10,899,760 B2Granted
Processes for preparing an FGFR inhibitor
AssigneePrincipia Biopharma Inc.
InventorsJiang Zhu, Mohammad Masjedizadeh
Life of this patent
Estimating the term…
Abstract
Disclosed herein are processes for preparing 8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one and FGFR inhibitor, as well as polymorphs and/or salt forms thereof.
Claims12
A process of preparing a compound of formula (I):
- comprising:
- (A) treating compound of formula (a), where X is a leaving group under elimination reaction conditions, with a base
- to provide the compound of formula (I);
- or
- (B) reducing the acetylene bond in compound (b)
- to provide the compound of formula (I);
- or
- (C) treating a compound of formula (c) with a reducing agent
- to provide the compound of formula (I);
- or
- (D) chlorinating a compound of formula (d)
- to provide the compound of formula (I).
9 more elements
Dependencies are inferred from the claim text.